妊娠期接触有机磷酸酯类阻燃剂与儿童肥胖风险：环境对儿童健康结果的影响联盟

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2024-10-17 DOI:10.1016/j.envint.2024.109071

Alicia K. Peterson , Stacey E. Alexeeff , Jennifer L. Ames , Juanran Feng , Cathleen Yoshida , Lyndsay A. Avalos , Emily S. Barrett , Theresa M. Bastain , Deborah H. Bennett , Jessie P. Buckley , Lisa A. Croen , Anne L. Dunlop , Monique M. Hedderson , Julie B. Herbstman , Kurunthachalam Kannan , Margaret R. Karagas , Cindy T McEvoy , Thomas G. O’Connor , Megan E. Romano , Sheela Sathyanarayana , Assiamira Ferrara

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引用次数: 0

摘要

简介：有机磷酸酯（OPE）越来越多地被用作阻燃剂和增塑剂，其干扰内分泌的活性和可能导致肥胖的后果引起了人们的关注。然而，有关妊娠期 OPE 暴露和儿童肥胖的纵向研究却很少。本研究探讨了孕期母体尿液中的 OPE 水平是否与儿童肥胖风险有关。方法：对 "环境对儿童健康结果的影响（ECHO）队列 "的 14 项研究中 5087 人的孕期尿液样本中的 OPE 进行了分析。在 > 80 % 的样本中检测到的 BDCPP、DBUP/DIBP 和 DPHP 被连续建模并按三等分建模；而在 50-80 % 的样本中检测到的 BCPP、BBOEP 和 BCETP 被分类建模（未检测到、低和高）。根据世界卫生组织（<2 岁）和美国疾病预防控制中心（CDC）（≥2 岁）的指标，儿童肥胖的定义是体重指数 z 值≥ 第 95 百分位数。调整后的修正泊松回归模型评估了儿童肥胖风险，贝叶斯核机器回归（BKMR）评估了混合效应。结果有 3,827 名婴儿期（0.5-1.9 岁）、3,921 名幼儿期（2.0-4.9 岁）和 2,541 名儿童中期（5.0-10.0 岁）儿童的 BMI 测量数据。各年龄组中，16%-21%的儿童患有肥胖症。在儿童中期，DBUP/DIBP 第二和第三等级与第一等级相比与肥胖风险增加有关（RR 1.14; 95 % CI: 1.02, 1.28; RR 1.11; 95 % CI: 0.97, 1.27; 分别为 1.14 和 1.27）；而 BDCPP 第二和第三等级与第一等级相比与肥胖风险呈反向关系（RR 0.85; 95 % CI: 0.80, 0.91 和 RR 0.91; 95 % CI: 0.77, 1.07; 分别为 0.85 和 0.91; 95 % CI: 0.77, 1.07）。DPHP、BCPP、BBOEP 和 BCETP 与肥胖风险没有关联。观察到的方向与 BKMR 模型中的方向一致。结论：这项研究确定了妊娠期 OPE 暴露与儿童肥胖之间的混合关联。有必要对各种 OPE 暴露进行进一步调查。

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Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium

Introduction: Organophosphate esters (OPEs) are increasing in use as flame retardants and plasticizers and concerns have been raised given their endocrine-disrupting activities and possible obesogenic consequences. However, longitudinal studies on gestational OPE exposure and childhood obesity are scarce. This study examined whether OPE levels in maternal urine during pregnancy were associated with the risk of childhood obesity. Methods: OPEs were analyzed in pregnancy urine samples of 5,087 individuals from 14 studies contributing to the Environmental influences on Child Health Outcomes (ECHO) Cohort. BDCPP, DBUP/DIBP, and DPHP, detected in > 80 % of the samples, were modeled continuously and by tertiles; whereas BCPP, BBOEP, and BCETP, detected in 50–80 % of samples, were modeled categorically (not-detected, low, and high). Childhood obesity was defined by BMI z-score ≥ 95th percentile according to WHO (<2 years) and the CDC (≥2 years) metrics. Adjusted modified Poisson regression models assessed childhood obesity risk and the mixture effect was assessed using Bayesian kernel machine regression (BKMR). Results: BMI measurements were available for 3,827 children in infancy (0.5–1.9 years), 3,921 children in early childhood (2.0–4.9 years), and 2,541 children in mid-childhood (5.0–10.0 years). Obesity was present in 16–21 % of children across age groups. In mid-childhood DBUP/DIBP second and third versus first tertiles were associated with increased obesity risk (RR 1.14; 95 % CI: 1.02, 1.28; and RR 1.11; 95 % CI: 0.97, 1.27; respectively); whereas BDCPP second and third versus first tertiles reflected an inverse association with obesity risk (RR 0.85; 95 % CI: 0.80, 0.91 and RR 0.91; 95 % CI: 0.77, 1.07; respectively). No association with obesity risk was observed for DPHP, BCPP, BBOEP, and BCETP. Directions observed were consistent with those seen in BKMR models. Conclusions: This study identified mixed associations between gestational OPE exposure and childhood obesity. Further investigation across a comprehensive range of OPE exposures is warranted.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.