视网膜变性疾病中的翻译后修饰：分子基础和治疗的最新进展

Brain-X Pub Date : 2024-10-15 DOI:10.1002/brx2.70005

Ke Yao, Qianxue Mou, Zhen Jiang, Yin Zhao

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引用次数: 0

摘要

非遗传性疾病和老年性视力丧失通常与视网膜变性有关。视网膜是一种后凋亡神经组织，缺乏内源性再生能力。因此，了解疾病导致视网膜退化的机制至关重要。翻译后修饰（PTM）决定了蛋白质在生理和病理过程中的功能，包括信号转导、蛋白质定位和蛋白质活化。先进的检测技术已经发现了 400 多种不同的 PTM，包括乙酰化、甲基化、磷酸化、泛素化和 SUMOylation。在此，我们将讨论视网膜变性疾病中的 PTMs，以帮助我们了解这些疾病的分子基础，并为未来潜在的临床治疗提供建议。

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Posttranslational modifications in retinal degeneration diseases: An update on the molecular basis and treatment

Noninherited diseases and age-associated vision loss are often associated with retinal degeneration. The retina is a postmitotic neural tissue lacking endogenous regeneration capacity. Therefore, understanding the mechanism of retinal degeneration in diseases is pivotal. Posttranslational modifications (PTMs) determine protein function during physiological and pathological processes, including signal transduction, protein localization, and protein activation. Advanced detection technologies have revealed over 400 different PTMs including acetylation, methylation, phosphorylation, ubiquitination and SUMOylation. Here, we discuss PTMs in retinal degeneration diseases to aid in our understanding of their molecular basis and suggest potential future clinical treatment.

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Brain-X

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