{"title":"封面专题：钴（III）与天然黄酮类化合物 Chrysin 和 Silibinin 的光活化抗癌活性（ChemBioChem 20/2024）","authors":"Jyotirmoy Dutta, Arpan Bera, Aarti Upadhyay, Ashish Kumar Yadav, Samya Banerjee, Tukki Sarkar, Akhtar Hussain","doi":"10.1002/cbic.202482002","DOIUrl":null,"url":null,"abstract":"<p>The article 10.1002/cbic.202400484 by Samya Banerjee, Tukki Sarkar, Akhtar Hussain, and co-workers highlights the synthesis, characterization, and evaluation of six new mixed-ligand cobalt(III) complexes for photodynamic therapy (PDT) in cancer treatment. Notably, complexes <b>Co5</b> and <b>Co6</b>, featuring dipyridophenazine and the naturally occurring flavonoids chrysin and silibinin, exhibit significant toxicity against cervical and lung cancer cells under visible light with low micromolar IC<sub>50</sub> values, while showing minimal toxicity in the absence of light. These complexes induce apoptosis via singlet oxygen generation following a type-II PDT pathway, displaying remarkable selectivity and biocompatibility for potential cancer PDT applications.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202482002","citationCount":"0","resultStr":"{\"title\":\"Cover Feature: Photoactivated Anticancer Activity of Cobalt(III) Complexes with Naturally Occurring Flavonoids Chrysin and Silibinin (ChemBioChem 20/2024)\",\"authors\":\"Jyotirmoy Dutta, Arpan Bera, Aarti Upadhyay, Ashish Kumar Yadav, Samya Banerjee, Tukki Sarkar, Akhtar Hussain\",\"doi\":\"10.1002/cbic.202482002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The article 10.1002/cbic.202400484 by Samya Banerjee, Tukki Sarkar, Akhtar Hussain, and co-workers highlights the synthesis, characterization, and evaluation of six new mixed-ligand cobalt(III) complexes for photodynamic therapy (PDT) in cancer treatment. Notably, complexes <b>Co5</b> and <b>Co6</b>, featuring dipyridophenazine and the naturally occurring flavonoids chrysin and silibinin, exhibit significant toxicity against cervical and lung cancer cells under visible light with low micromolar IC<sub>50</sub> values, while showing minimal toxicity in the absence of light. These complexes induce apoptosis via singlet oxygen generation following a type-II PDT pathway, displaying remarkable selectivity and biocompatibility for potential cancer PDT applications.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202482002\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202482002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202482002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Cover Feature: Photoactivated Anticancer Activity of Cobalt(III) Complexes with Naturally Occurring Flavonoids Chrysin and Silibinin (ChemBioChem 20/2024)
The article 10.1002/cbic.202400484 by Samya Banerjee, Tukki Sarkar, Akhtar Hussain, and co-workers highlights the synthesis, characterization, and evaluation of six new mixed-ligand cobalt(III) complexes for photodynamic therapy (PDT) in cancer treatment. Notably, complexes Co5 and Co6, featuring dipyridophenazine and the naturally occurring flavonoids chrysin and silibinin, exhibit significant toxicity against cervical and lung cancer cells under visible light with low micromolar IC50 values, while showing minimal toxicity in the absence of light. These complexes induce apoptosis via singlet oxygen generation following a type-II PDT pathway, displaying remarkable selectivity and biocompatibility for potential cancer PDT applications.
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