封面：3-(二甲基氨基)丙酸乙烯酯作为不可逆酰基给体试剂用于无色谱脂肪酶催化的仲醇动力学解析（ChemBioChem 20/2024）

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2024-10-16 DOI:10.1002/cbic.202482001

Beata Zdun, Dr. Paweł Borowiecki

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引用次数: 0

摘要

封面图片展示了一种新型 "可酸洗 "酰基给体，即 3-(二甲基氨基)丙酸乙烯酯，专用于外消旋仲醇的无色谱脂肪酶催化动力学解析（KR）。所采用的乙烯基酯能够以高转化率和出色的对映体选择性合成一系列结构多样的苄醇的两种对映体，最重要的是，通过消除硅胶色谱分离，大大简化了酶促 KR，从而实现了一种更具可持续性和生态友好型的生物工艺。更多详情请见 Beata Zdun 和 Paweł Borowiecki 的文章 10.1002/cbic.202400394。封面图片由 Paweł Borowiecki 设计，Paulina Marek-Urban 制作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Front Cover: Vinyl 3-(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography-free Lipase-Catalyzed Kinetic Resolution of sec-Alcohols (ChemBioChem 20/2024)

The cover image depicts a novel “acid-washable” acyl donor, namely vinyl 3-(dimethylamino)propanoate, dedicated to a chromatography-free lipase-catalyzed kinetic resolution (KR) of racemic sec-alcohols. The employed vinyl ester allows the synthesis of both enantiomers of a range of structurally diverse benzylic alcohols with high conversions and excellent enantioselectivity, and, most importantly, significantly simplifies enzymatic KR by eliminating a silica gel chromatographic separation, leading to a more sustainable and ecologically friendly bioprocess. More details can be found in article 10.1002/cbic.202400394 by Beata Zdun and Paweł Borowiecki. Cover image designed by Paweł Borowiecki and created by Paulina Marek-Urban.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).