细菌光调节腺苷酸环化酶 bPAC 和 OaPAC 的动态行为比较研究

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI:10.3103/S0027131424700251

M. S. Kuryshkina, A. M. Kulakova, A. A. Moskovsky, M. G. Khrenova

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引用次数: 0

摘要

利用经典分子动力学方法比较了光调节腺苷酸环化酶 bPAC 和 OaPAC 在光照射前后的状态。确定了从感光结构域到催化结构域的信号转导途径。bPAC 在光照射后催化反应的加速更为明显，这既是由于平衡向封闭构象的转变，也是由于从一个结构域到另一个结构域的异位信号转导的次优途径数量显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Comparative Study of the Dynamic Behavior of Bacterial Photoregulated Adenylate Cyclases bPAC and OaPAC

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A Comparative Study of the Dynamic Behavior of Bacterial Photoregulated Adenylate Cyclases bPAC and OaPAC

Photoregulated adenylate cyclases bPAC and OaPAC are compared using methods of classical molecular dynamics in the states before and after irradiation with light. The pathways of signal transduction from the photoreceptor domain to the catalytic domain are determined. The more pronounced acceleration of the catalytic reaction as a result of irradiation with light in the case of bPAC is determined both by a shift of the equilibrium towards a closed conformation and a more significant increase in the number of suboptimal pathways of allosteric signal transduction from one domain to another.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.