从蔷薇中合成氧化锌纳米粒子的生物功效及其生物和环境应用

Q1 Environmental Science

Toxicology Reports Pub Date : 2024-10-09 DOI:10.1016/j.toxrep.2024.101758

Ramachandran Adhavan , Kuppusamy Selvam , Palanisamy Prakash , Peraman Manimegalai , Dharmalingam Kirubakaran , Muthugounder Subramanian Shivakumar

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引用次数: 0

摘要

由于药用植物对环境无害，利用药用植物合成金属氧化物纳米粒子的研究正在迅速增加。本研究利用蔷薇叶提取物合成了氧化锌纳米粒子。利用紫外可见光谱分析对合成的纳米粒子进行了表征，在 374 纳米处观察到带隙为 2.5 eV 的峰值，傅立叶变换红外光谱和 X 射线衍射分析验证了纳米粒子的纯六边形结构，通过扫描电镜和电离辐射 X 分析确认了纳米粒子的球形形状，主要化合物为 75% 的锌和 22% 的氧。透射电子显微镜分析证实了氧化锌纳米粒子的椭圆形生物活性，如抗氧化试验 DPPH、ABTS 和羟基自由基活性显示了对自由基的良好抑制作用。体外降血糖作用对 α- 淀粉酶活性的最大抑制率为 96%，对 α- 糖苷酶活性的最大抑制率为 87%。抗炎活性在白蛋白变性试验中的最大抑制率为 93%，在膜稳定试验中的抑制率为 75%。E. roseum ZnO NPs 对 HepG2 抗增殖细胞系的抑制率为 67.79%。AO/EtBr 染色试验证实了凋亡效应。杀幼虫活性显示，对 C. quinquefasciatus 的最高死亡率为 98.44%。光催化降解亚甲基蓝染料的效果为 65%。

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Bioefficacy of Zinc oxide nanoparticle synthesis and their Biological, Environmental applications from Eranthemum roseum

Synthesis of metal oxide nanoparticles using medicinal plants increasing rapidly due to its eco-friendly to environment. In this study Zinc oxide nanoparticle is synthesized using the leaf extract of plant E. roseum. Synthesized NPs was characterized using UV- Vis Spectroscopy analysis where the peak observed at 374 nm with band gap of 2.5 eV, FTIR and XRD analysis validate pure hexagonal structure, Spherical shape of NPs was confirmed by SEM with EDX analysis and main compounds are zinc 75 % and oxygen 22 %. Transmission Electron Microscopy Analysis confirms the oval shaped ZnO NPs Biological activity of E. roseum ZnO NPs such as antioxidant assay DPPH, ABTS, hydroxyl radical activity shows good inhibition against free radicals. The In-vitro Hypoglycemic effects has maximum inhibition of 96 % on α- amylase activity and 87 % on α- Glycosidase activity. Anti-inflammatory activity recorded 93 % maximum inhibition at Albumin denaturation assay and 75 % at Membrane stabilization assay. E. roseum ZnO NPs shows 67.79 % on HepG2 Anti-proliferative cells line. AO/EtBr staining assays confirms the apoptosis effect. Larvicidal activity shows highest mortality of 98.44 % on species C. quinquefasciatus. Photocatalytic dyedegradation of Methylene blue dye shows 65 % of dye degradation.

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