阿斯利康 COVID-19 疫苗第二剂接种后不良反应的性别差异：一项针对医护人员的横断面研究

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2024-10-16 DOI:10.1016/j.vaccine.2024.126424

Masoud Sedaghat , Badriyeh Karami , Farid Najafi , Fatemeh Khosravi Shadmani , Shahab Rezaeian

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引用次数: 0

摘要

背景：大流行性疾病的疫苗接种除了对控制流行和减少由此产生的社会经济影响有积极作用外，还可能因性别、疫苗类型和剂量的不同而产生不同强度的不良反应。我们旨在调查医护人员接种第二剂阿斯利康 Covid-19 疫苗后不良反应的性别差异：这项横断面研究的对象是在伊朗西部克尔曼沙阿市两家教育医院工作并接种过第二剂阿斯利康疫苗的 780 名医护人员。不良反应的调查时间最长为接种第二剂阿斯利康疫苗后一个月：女性参与者在接种第二剂阿斯利康Covid-19疫苗后出现不良反应的总体比例较高，但并不显著（OR=1.83，P=0.056）。调整后的逻辑回归结果显示，寒战（OR=2.17，p=0.001）、恶心（OR=2.98，p=0.012）、胃肠道症状（OR=2.1，p=0.001）、流鼻涕（OR=1.5，P=0.047）、发烧（OR=1.64，P=0.002）、身体疼痛（OR=1.4，P=0.04）和疲劳（OR=1.85，P=0.001），女性明显高于男性。发热不良反应在两性之间的最大差距为 15%（归因风险）：女性接种阿斯利康 Covid-19 疫苗第二剂后出现副作用的比例较高，这表明性别因素会影响对疫苗的反应，因此，女性必须接受进一步检查，以降低注射过程中出现并发症的风险。

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Gender differences in adverse effects following the second dose of AstraZeneca COVID-19 vaccine: a cross-sectional study among healthcare workers

Background: Vaccination in pandemic diseases, in addition to positive effects on controlling the prevalence and reducing the resulting socioeconomic effects, can have adverse effects with different intensity based on gender, type and dose of vaccine. We aimed to investigate gender differences in adverse effects following the second dose of AstraZeneca Covid-19 vaccine among healthcare workers (HWs).

Method: This cross-sectional study was conducted on 780 HWs who worked in two educational hospitals in Kermanshah city, western Iran, and had received the second dose of AstraZeneca vaccine. The duration of the investigation of the adverse effects was a maximum of one month after receiving the second dose of AstraZeneca vaccine.

Results: The overall proportion of adverse effects following the second dose of the AstraZeneca Covid-19 vaccine was higher in female participants, but it was not significant (OR=1.83, p=0.056). The results of adjusted logistic regression showed that the odds of chills (OR=2.17, p=0.001), nausea (OR=2.98, p=0.012), and gastrointestinal symptoms (OR=2.1, p=0.001), runny nose (OR=1.5, p=0.047), fever (OR=1.64, p=0.002), body pain (OR=1.4, p=0.04), and fatigue (OR=1.85, p=0.001) were significantly higher in females than in males. The maximum gap of 15% (attributable risk) was shown for fever adverse between genders.

Conclusion: The higher occurrence rate of side effects after second dose of AstraZeneca Covid-19 vaccine in women, indicates that gender factors influence the response to the vaccine, consequently, it is imperative that women undergo further examination to mitigate the risk of complications arising from injection procedures.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.