难治性IgM AL淀粉样变性伴巨大软组织肿瘤:扎努布替尼的救治。病例报告

IF 0.2 Q4 ONCOLOGY
Piotr Jachimowski , Łukasz Ciulkiewicz , Mateusz Ziarkiewicz , Bogna Ziarkiewicz-Wróblewska , Marta Legatowicz-Koprowska , Krzysztof Jamroziak
{"title":"难治性IgM AL淀粉样变性伴巨大软组织肿瘤:扎努布替尼的救治。病例报告","authors":"Piotr Jachimowski ,&nbsp;Łukasz Ciulkiewicz ,&nbsp;Mateusz Ziarkiewicz ,&nbsp;Bogna Ziarkiewicz-Wróblewska ,&nbsp;Marta Legatowicz-Koprowska ,&nbsp;Krzysztof Jamroziak","doi":"10.1016/j.cpccr.2024.100325","DOIUrl":null,"url":null,"abstract":"<div><div>Waldenström macroglobulinemia (WM) is a rare indolent B-cell non-Hodgkin lymphoma with lymphoplasmacytic morphology, associated with immunoglobulin M (IgM) monoclonal gammopathy. The coexistence of WM and immunoglobulin light chain (AL) amyloidosis is an uncommon but well-described phenomenon. In patients suffering from IgM AL amyloidosis soft tissue involvement and neuropathy are more prevalent in comparison to non-IgM patients. We present a case of 82-year old female with WM and intercurrent IgM AL amyloidosis, presenting with massive amyloidomas of both lower extremities, without significant cardiac and renal involvement. The patient was refractory to several lines of treatment and finally started on zanubrutinib monotherapy, with rapid and sustained very good partial hematologic response (VGPR) and clinical improvement.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"16 ","pages":"Article 100325"},"PeriodicalIF":0.2000,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Refractory IgM AL amyloidosis with massive soft tissue tumors: Rescue with zanubrutinib. A case report\",\"authors\":\"Piotr Jachimowski ,&nbsp;Łukasz Ciulkiewicz ,&nbsp;Mateusz Ziarkiewicz ,&nbsp;Bogna Ziarkiewicz-Wróblewska ,&nbsp;Marta Legatowicz-Koprowska ,&nbsp;Krzysztof Jamroziak\",\"doi\":\"10.1016/j.cpccr.2024.100325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Waldenström macroglobulinemia (WM) is a rare indolent B-cell non-Hodgkin lymphoma with lymphoplasmacytic morphology, associated with immunoglobulin M (IgM) monoclonal gammopathy. The coexistence of WM and immunoglobulin light chain (AL) amyloidosis is an uncommon but well-described phenomenon. In patients suffering from IgM AL amyloidosis soft tissue involvement and neuropathy are more prevalent in comparison to non-IgM patients. We present a case of 82-year old female with WM and intercurrent IgM AL amyloidosis, presenting with massive amyloidomas of both lower extremities, without significant cardiac and renal involvement. The patient was refractory to several lines of treatment and finally started on zanubrutinib monotherapy, with rapid and sustained very good partial hematologic response (VGPR) and clinical improvement.</div></div>\",\"PeriodicalId\":72741,\"journal\":{\"name\":\"Current problems in cancer. Case reports\",\"volume\":\"16 \",\"pages\":\"Article 100325\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-10-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current problems in cancer. Case reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666621924000486\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666621924000486","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

瓦尔登斯特伦巨球蛋白血症(WM)是一种罕见的非霍奇金B细胞淋巴瘤,具有淋巴浆细胞形态,伴有免疫球蛋白M(IgM)单克隆性腺病。WM与免疫球蛋白轻链(AL)淀粉样变性同时存在,这种现象并不常见,但已被详细描述。与非 IgM 患者相比,IgM AL 淀粉样变性患者的软组织受累和神经病变更为普遍。我们报告了一例82岁的女性患者,她患有WM和并发症IgM AL淀粉样变性,双下肢出现大量淀粉样变瘤,但没有明显的心脏和肾脏受累。患者对多种治疗方法均无效,最后开始接受扎鲁替尼单药治疗,并获得了快速、持续的非常好的部分血液学反应(VGPR)和临床改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Refractory IgM AL amyloidosis with massive soft tissue tumors: Rescue with zanubrutinib. A case report
Waldenström macroglobulinemia (WM) is a rare indolent B-cell non-Hodgkin lymphoma with lymphoplasmacytic morphology, associated with immunoglobulin M (IgM) monoclonal gammopathy. The coexistence of WM and immunoglobulin light chain (AL) amyloidosis is an uncommon but well-described phenomenon. In patients suffering from IgM AL amyloidosis soft tissue involvement and neuropathy are more prevalent in comparison to non-IgM patients. We present a case of 82-year old female with WM and intercurrent IgM AL amyloidosis, presenting with massive amyloidomas of both lower extremities, without significant cardiac and renal involvement. The patient was refractory to several lines of treatment and finally started on zanubrutinib monotherapy, with rapid and sustained very good partial hematologic response (VGPR) and clinical improvement.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
96 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信