现在，它在心脏器官组织中变得鲜血淋漓

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-10-16 DOI:10.1038/s41556-024-01528-2

Thomas Brand

引用次数: 0

摘要

在器官组织中模拟确定性造血一直是一项挑战。现在，一项研究开发出了可生成血液的心脏形成类器官，这种类器官可显示心肌、血管内皮形成和最终造血。这种类器官是人类胚胎循环系统发育的体外模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Now it’s getting bloody in cardiac organoids

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Now it’s getting bloody in cardiac organoids

Modelling definitive haematopoiesis in organoids has been challenging. A study now develops blood-generating heart-forming organoids that display heart muscle, vascular endothelium formation and definitive haematopoiesis. This organoid represents an in vitro model of human embryonic circulatory system development.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology