通过乳酸依赖性组蛋白乳酰化实现 CD8+ T 细胞的代谢-表观遗传重新布线

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-10-16 DOI:10.1038/s41590-024-01991-x

Renqiang Sun, Hongbo Chi

引用次数: 0

摘要

代谢物与表观遗传程序的相互作用影响着 CD8+ T 细胞的命运决定。在这里，Raychaudhuri 等人发现，乳酸依赖性组蛋白乳酰化通过调节表观遗传和转录重塑来调整 CD8+ T 细胞的新陈代谢和功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation

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Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation

The interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent histone lactylation tunes CD8+ T cell metabolism and function by regulating epigenetic and transcriptional remodeling.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.