{"title":"基于木聚糖的双向吸收和再分配、生物刺激响应型纳米给药系统,用于增强非系统农药在大豆植物中的转运能力","authors":"Qiuyu Xiong, Zhengang Xie, Bin Yu, Zifeng Yang, Haonan Zhang, Yun Fang, Jingli Cheng, Jinhao Zhao","doi":"10.1016/j.cej.2024.156310","DOIUrl":null,"url":null,"abstract":"Non-systemic pesticides, like fludioxonil, have the advantages of broad-spectrum and fast-acting, but the limited space of action restricts their effectiveness. This study proposed a nano-delivery strategy (Flu@EXG) by loading fludioxonil on aminated xyloglucan-based nanoparticles (EXG) to enhance the systematicity of fludioxonil <em>in vivo</em> and consequently achieve systemic defense against soybean diseases. The resulting Flu@EXG had an average diameter of 75.6 nm and exhibited responsive release properties to dual-stimuli of hemicellulases and pH value. The combined measurements of target dose and efficacy demonstrated that the Flu@EXG achieved bi-directional uptake and redistribution of fludioxonil, consequently inhibiting both <em>Phytophthora sojae</em> in roots and <em>Botrytis cinerea</em> on leaves meanwhile with a single application method (root irrigation or foliar spraying) in soybean. In contrast, fludioxonil commercial suspensions (Flu SC) hardly reached the roots to control root diseases when applied to foliage. Additionally, the direct inhibition of Flu@EXG against oomycetes was 2.0 times higher than Flu SC at high test concentrations as EXG could directly provide additional membrane damage. Finally, Flu@EXG provided comparable foliar performance to Flu SC and do not affect the growth of soybeans during the test cycle. Thus, the bio-stimuli responsive Flu@EXG nanodelivery system has promising for achieving the systemic prevention by overcoming the spatial and temporal limitations of non-systemic pesticide application, providing new perspectives and technologies for prompting sustainable development of agriculture.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":null,"pages":null},"PeriodicalIF":13.3000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bidirectional uptake and redistribution, bio-stimuli responsive xyloglucan-based nanodelivery system for enhanced translocation of non-systemic pesticide in soybean plants\",\"authors\":\"Qiuyu Xiong, Zhengang Xie, Bin Yu, Zifeng Yang, Haonan Zhang, Yun Fang, Jingli Cheng, Jinhao Zhao\",\"doi\":\"10.1016/j.cej.2024.156310\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Non-systemic pesticides, like fludioxonil, have the advantages of broad-spectrum and fast-acting, but the limited space of action restricts their effectiveness. This study proposed a nano-delivery strategy (Flu@EXG) by loading fludioxonil on aminated xyloglucan-based nanoparticles (EXG) to enhance the systematicity of fludioxonil <em>in vivo</em> and consequently achieve systemic defense against soybean diseases. The resulting Flu@EXG had an average diameter of 75.6 nm and exhibited responsive release properties to dual-stimuli of hemicellulases and pH value. The combined measurements of target dose and efficacy demonstrated that the Flu@EXG achieved bi-directional uptake and redistribution of fludioxonil, consequently inhibiting both <em>Phytophthora sojae</em> in roots and <em>Botrytis cinerea</em> on leaves meanwhile with a single application method (root irrigation or foliar spraying) in soybean. In contrast, fludioxonil commercial suspensions (Flu SC) hardly reached the roots to control root diseases when applied to foliage. Additionally, the direct inhibition of Flu@EXG against oomycetes was 2.0 times higher than Flu SC at high test concentrations as EXG could directly provide additional membrane damage. Finally, Flu@EXG provided comparable foliar performance to Flu SC and do not affect the growth of soybeans during the test cycle. Thus, the bio-stimuli responsive Flu@EXG nanodelivery system has promising for achieving the systemic prevention by overcoming the spatial and temporal limitations of non-systemic pesticide application, providing new perspectives and technologies for prompting sustainable development of agriculture.\",\"PeriodicalId\":270,\"journal\":{\"name\":\"Chemical Engineering Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.3000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Engineering Journal\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cej.2024.156310\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.cej.2024.156310","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Bidirectional uptake and redistribution, bio-stimuli responsive xyloglucan-based nanodelivery system for enhanced translocation of non-systemic pesticide in soybean plants
Non-systemic pesticides, like fludioxonil, have the advantages of broad-spectrum and fast-acting, but the limited space of action restricts their effectiveness. This study proposed a nano-delivery strategy (Flu@EXG) by loading fludioxonil on aminated xyloglucan-based nanoparticles (EXG) to enhance the systematicity of fludioxonil in vivo and consequently achieve systemic defense against soybean diseases. The resulting Flu@EXG had an average diameter of 75.6 nm and exhibited responsive release properties to dual-stimuli of hemicellulases and pH value. The combined measurements of target dose and efficacy demonstrated that the Flu@EXG achieved bi-directional uptake and redistribution of fludioxonil, consequently inhibiting both Phytophthora sojae in roots and Botrytis cinerea on leaves meanwhile with a single application method (root irrigation or foliar spraying) in soybean. In contrast, fludioxonil commercial suspensions (Flu SC) hardly reached the roots to control root diseases when applied to foliage. Additionally, the direct inhibition of Flu@EXG against oomycetes was 2.0 times higher than Flu SC at high test concentrations as EXG could directly provide additional membrane damage. Finally, Flu@EXG provided comparable foliar performance to Flu SC and do not affect the growth of soybeans during the test cycle. Thus, the bio-stimuli responsive Flu@EXG nanodelivery system has promising for achieving the systemic prevention by overcoming the spatial and temporal limitations of non-systemic pesticide application, providing new perspectives and technologies for prompting sustainable development of agriculture.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.