C. L. Pappe, S. Lutzenberger, K. Goebler, S. Meier, M. Jeitler, A. Michalsen, H. Dommisch
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Periodontal examination included bleeding on probing (BOP), periodontal inflamed surface area (PISA) and plaque index (PI) on six index teeth, salivary pH and matrix-matalloproteinase-8 (MMP-8).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>At <i>t</i>3, the mean PISA of the index teeth was reduced by 32 mm<sup>2</sup> (53.8) in the WPBD group and increased by 22.6 mm<sup>2</sup> (45.1) in the CG group (intra-group <i>p</i> = 0.255 and <i>p</i> = 0.977, respectively), BOP changes were similar (intra-group <i>p</i> = 0.89 and <i>p</i> = 0.839, respectively). MMP-8 values reduced in the WPBD group by 50.73 ng/mL (117) and in the CG by 5.40 ng/mL (96.6) (intra-group <i>p</i> = 0.066, <i>p</i> = 0.837, respectively). Difference in change (<i>t</i>3 − <i>t</i>1) between the groups was <i>p</i> = 0.001, <i>p</i> = 0.003 and <i>p</i> = 0.032, respectively. Saliva pH increased in the WPBD group only (intra-group <i>p</i> = 0.007).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>A trend towards stabilization of the inflammatory parameters (BOP, PISA) was observed in the WPBD group. Because of the non-significant changes within the groups, this study highlights the imperative for future studies.</p>\n </section>\n \n <section>\n \n <h3> ClinicalTrials.gov identifier</h3>\n \n <p>NCT03901183.</p>\n </section>\n </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 1","pages":"125-136"},"PeriodicalIF":5.8000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14066","citationCount":"0","resultStr":"{\"title\":\"Effect of a Whole-Food Plant-Based Diet on Periodontal Parameters in Patients With Cardiovascular Risk Factors: A Secondary Sub-Analysis of a Randomized Clinical Trial\",\"authors\":\"C. L. Pappe, S. Lutzenberger, K. Goebler, S. Meier, M. Jeitler, A. Michalsen, H. 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引用次数: 0
摘要
材料和方法一项随机临床试验的 36 名参与者接受了额外的牙周评估。干预组（n = 17）接受为期 16 周的 WPBD，而对照组（n = 19）则接受不改变饮食习惯的指导。分别在基线（t1）、第 8 周（t2）和第 16 周（t3）进行评估。牙周检查包括探诊出血（BOP）、牙周炎症表面积（PISA）和六颗牙齿的牙菌斑指数（PI）、唾液 pH 值和基质金属蛋白酶-8（MMP-8）。8），CG 组增加了 22.6 平方毫米（45.1）（组内 p = 0.255 和 p = 0.977），BOP 变化相似（组内 p = 0.89 和 p = 0.839）。WPBD 组的 MMP-8 值减少了 50.73 纳克/毫升（117），CG 组减少了 5.40 纳克/毫升（96.6）（组内 p = 0.066，组间 p = 0.837）。组间变化（t3 - t1）差异分别为 p = 0.001、p = 0.003 和 p = 0.032。结论 WPBD 组的炎症参数（BOP、PISA）呈稳定趋势。由于组内变化不显著，本研究强调了未来研究的必要性。
Effect of a Whole-Food Plant-Based Diet on Periodontal Parameters in Patients With Cardiovascular Risk Factors: A Secondary Sub-Analysis of a Randomized Clinical Trial
Aim
To investigate the effect of a 16-week whole-food plant-based diet (WPBD) on periodontal parameters in patients with increased cardiometabolic risk.
Materials and Methods
A total of 36 participants from a randomized clinical trial received additional periodontal assessment. The intervention group (n = 17) followed a WPBD for 16 weeks, whereas the control group (CG) (n = 19) was instructed not to change their diet. Measurements were assessed at baseline (t1), week 8 (t2) and week 16 (t3). Periodontal examination included bleeding on probing (BOP), periodontal inflamed surface area (PISA) and plaque index (PI) on six index teeth, salivary pH and matrix-matalloproteinase-8 (MMP-8).
Results
At t3, the mean PISA of the index teeth was reduced by 32 mm2 (53.8) in the WPBD group and increased by 22.6 mm2 (45.1) in the CG group (intra-group p = 0.255 and p = 0.977, respectively), BOP changes were similar (intra-group p = 0.89 and p = 0.839, respectively). MMP-8 values reduced in the WPBD group by 50.73 ng/mL (117) and in the CG by 5.40 ng/mL (96.6) (intra-group p = 0.066, p = 0.837, respectively). Difference in change (t3 − t1) between the groups was p = 0.001, p = 0.003 and p = 0.032, respectively. Saliva pH increased in the WPBD group only (intra-group p = 0.007).
Conclusion
A trend towards stabilization of the inflammatory parameters (BOP, PISA) was observed in the WPBD group. Because of the non-significant changes within the groups, this study highlights the imperative for future studies.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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