让脂质变得非常不开心，以发现它们是如何与蛋白质结合的。

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-10-15 DOI:10.1083/jcb.202410022

Christopher Stefan,Roberto Covino

引用次数: 0

摘要

膜脂组成由保守的脂质转移蛋白维持，但研究其脂质结合机制的计算方法却受到限制。Srinivasan 等人（https://doi.org/10.1083/jcb.202312055）开发了一种巧妙的分子动力学模拟测定法，以准确模拟脂质转移蛋白的脂质结合姿势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Making lipids very unhappy to discover how they bind to proteins.

Membrane lipid composition is maintained by conserved lipid transfer proteins, but computational approaches to study their lipid-binding mechanisms are limiting. Srinivasan et al. (https://doi.org/10.1083/jcb.202312055) develop a clever molecular dynamics simulations assay to accurately model lipid-binding poses in lipid transfer proteins.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.