E. V. Pronskikh, I. A. Kolesnikova, Yu. S. Severiukhin, D. M. Utina, K. N. Golikova, T. S. Khramko, M. Lalcovicova, A. G. Molokanov
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Study of the Modifying Effect of 1-β-D-Arabinofuranosyl Cytosine on the Immune Status of Rats in the Long Period under the Exposure to Protons
The effect of the combined use of protons at a dose of 3 Gy and 1-β-D-arabinofuranosylcytosine (Ara-C) on the physiological parameters of immunocompetent organs on the 90th day was studied: the weight of the spleen, thymus, total leukocyte count, and leukogram were examined. A significant decrease in thymus mass was established under the combined action of protons and Ara-C; a trend was observed in all experimental groups towards a decrease in spleen weight compared to the reference group. A statistically significant increase in the number of leukocytes in the “Ara-C” group was revealed, without differences in their types distribution during visual differentiated counting. It is concluded that further research of combined use of the DNA replication and Ara-C repair inhibitor and various types of ionizing radiation may be a promising way for extending the therapeutic capabilities of oncological practice.
期刊介绍：
The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
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