乳香和乳香中的三萜类化合物：药理学和 13C-NMR 分析的重点

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-10-12 DOI:10.1016/j.phytochem.2024.114297

Najeeb Ur Rehman , Kashif Rafiq , Satya K. Avula , Simon Gibbons , René Csuk , Ahmed Al-Harrasi

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引用次数: 0

摘要

在此，我们首次报告了从具有重要药用价值的乳香属（其中包括极具文化价值的乳香物种）的油胶树脂中分离出的 119 种（共 127 种）三萜类化合物的全部 13C-NMR 图谱。本文介绍了 1998 年至 2024 年间分离的这些三萜类化合物的完整 13C-NMR 共振及其生物活性。13C-NMR 光谱是表征这些具有生物活性的天然产品的一个非常强大的工具。这些化合物按其骨架排列，即乌尔烷、齐墩果烷、羽扇豆烷、达玛烷和叽鲁呱烷三萜。这篇综述将为今后鉴定这些在细胞毒性和炎症领域具有关键药用特性的化合物提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Triterpenoids from Frankincense and Boswellia: A focus on their pharmacology and 13C-NMR assignments

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Triterpenoids from Frankincense and Boswellia: A focus on their pharmacology and 13C-NMR assignments

Here we report for the first time the entire ¹³C-NMR spectral assignments of 119 (out of 127) triterpenoids from the oleo-gum resins of the medicinally important genus Boswellia, which includes the culturally highly valuable Frankincense species. The complete ¹³C-NMR resonances of these triterpenoids isolated between 1998 and 2024 and their biological activities are presented. ¹³C-NMR spectroscopy is a highly powerful tool for the characterization of these bioactive natural products. The compounds are arranged according to their skeletons, i.e., ursane, oleanane, lupane, dammarane, and tirucallane triterpenes. This review will be a future reference for the identification of these compounds, which have key medicinal properties in the areas of cytotoxicity and inflammation.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.