广泛的反CRISPR战略

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-10-15 DOI:10.1038/s41589-024-01743-w

Yi Zhang, Yue Feng

引用次数: 0

摘要

原核生物的CRISPR-Cas系统会被噬菌体编码的反CRISPR元件抵消，它们如何保护自己仍然是个谜。一项研究表明，CRISPR抑制毒素通过诱导中止感染来保护CRISPR-Cas免受反CRISPR蛋白或RNA的侵害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A broad anti-anti-CRISPR strategy

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A broad anti-anti-CRISPR strategy

Prokaryotic CRISPR–Cas systems are counteracted by phage-encoded anti-CRISPR elements, and how they protect themselves remains enigmatic. A study shows that CRISPR-repressed toxins defend CRISPR–Cas against anti-CRISPR proteins or RNAs by inducing abortive infection.

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.