蛋白质-DNA 相互作用的第三条链

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2024-10-15 DOI:10.1038/s41557-024-01652-4

David A. Rusling, Karen M. Vasquez

引用次数: 0

摘要

我们开发了一种基于近距离标记的方法，可以检测特定蛋白质与活细胞中形成的内源性三重 DNA 序列的相互作用，从而大大扩展了与这些 DNA 结构相互作用的假定蛋白质的目录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A third strand for protein–DNA interactions

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A third strand for protein–DNA interactions

A method has been developed based on proximity labelling that detects the interaction of specific proteins with endogenous triplex DNA sequences formed in live cells — significantly expanding the catalogue of putative proteins that interact with these DNA structures.

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.