化脓性扁桃体炎炎症性关节炎的发病率和预测因素

IF 3.5 3区 医学 Q1 DERMATOLOGY
Sheena Maureen T. Sy, Lihi Eder, Dana Jerome, Chikaodili Obetta, Hayley McKee, Reza Mirza, Elisabeth Pek, Vincent Piguet, Raed Alhusayen
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引用次数: 0

摘要

化脓性扁桃体炎(HS)是一种慢性、使人衰弱的自身炎症,通常与炎症性关节炎伴发,严重影响患者的生活质量。这两种疾病的早期诊断对于优化治疗至关重要。本研究旨在确定 HS 患者中炎性关节炎的发病率和相关因素。这项横断面研究于 2021 年 11 月至 2023 年 2 月在加拿大的一家皮肤病学术中心进行。研究连续抽取了成年 HS 患者,52 名患者同意参与并完成了评估。研究变量包括年龄、性别、HS严重程度、治疗、种族、家族史、生活方式因素和合并症。主要结果是风湿免疫科医生确诊的炎症性关节炎和相关风险因素。在 52 名患者中(男性 24 人,女性 28 人;平均年龄:37.4 岁),12 人患有炎症性关节炎。多变量分析显示,与白人相比,黑人(OR = 0.10,p <0.001,CI:0.026-0.343)和亚洲人(OR = 0.02,p <0.001,CI:0.005-0.109)患炎症性关节炎的几率较低。HS 发病年龄每增加 1 岁,患炎症性关节炎的几率就会增加 1.17 倍(OR:1.17,p < 0.001,CI:1.12-1.24)。吸烟(OR = 0.01,p < 0.001,CI:0.002-0.49)、高血压(OR:0.23,p = 0.04,CI:0.057-0.930)和抑郁(OR:0.12,p < 0.001,CI:0.041-0.330)会降低炎症性关节炎的几率。白种人和 HS 发病年龄较大与炎症性关节炎呈正相关,而吸烟、高血压和抑郁则呈负相关。这些研究结果表明,HS 患者中有一个独特的亚群患有炎症性关节炎,值得进一步开展前瞻性研究。这项研究有助于人们了解 HS 患者的炎症性关节炎,并强调了在皮肤科门诊就诊时转诊风湿免疫科的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and Predictors of Inflammatory Arthritis in Hidradenitis Suppurativa

Hidradenitis Suppurativa (HS) is a chronic, debilitating, auto-inflammatory condition often associated with inflammatory arthritis, significantly impacting patients' quality of life. Early diagnosis of both conditions is crucial for optimal management. The objective of this study was to determine the prevalence and factors associated with the development of inflammatory arthritis among HS patients. A cross-sectional study was conducted between November 2021 and February 2023 at an academic dermatology centre in Canada. Adult patients with HS were consecutively sampled, and 52 patients consented to participate and completed assessments. Variables examined included age, sex, HS severity, treatment, ethnicity, family history, lifestyle factors and comorbidities. The main outcomes were rheumatologist-confirmed inflammatory arthritis diagnosis and associated risk factors. Among 52 patients (24 males, 28 females; mean age: 37.4 years), 12 had inflammatory arthritis. Multivariate analysis revealed that Blacks (OR = 0.10, p < 0.001, CI: 0.026–0.343) and Asians (OR = 0.02, p < 0.001, CI: 0.005–0.109) had lower inflammatory arthritis odds compared to Whites. Every 1-year increase in age at HS onset correlated with a 1.17-fold increase in the odds of developing inflammatory arthritis (OR: 1.17, p < 0.001, CI: 1.12–1.24). Smoking (OR = 0.01, p < 0.001, CI: 0.002–0.49), hypertension (OR: 0.23, p = 0.04, CI: 0.057–0.930) and depression (OR: 0.12, p < 0.001, CI: 0.041–0.330) reduced inflammatory arthritis odds. White ethnicity and older age at HS onset were positively associated with inflammatory arthritis, while smoking, hypertension and depression were negatively associated. These findings suggest a distinct subset of HS patients with inflammatory arthritis that warrant further prospective studies. This study contributes to the understanding of inflammatory arthritis in HS patients and emphasises the importance of rheumatology referral during dermatologic clinic visits.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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