设计和制造用于光纤色谱和分拣的三维打印片上实验室设备

IF 3.7 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Ole Milark, Marc Buttkewitz, Emil Agócs, Beate Legutko, Benjamin Bergmann, Janina Bahnemann, Alexander Heisterkamp, Maria Leilani Torres-Mapa
{"title":"设计和制造用于光纤色谱和分拣的三维打印片上实验室设备","authors":"Ole Milark,&nbsp;Marc Buttkewitz,&nbsp;Emil Agócs,&nbsp;Beate Legutko,&nbsp;Benjamin Bergmann,&nbsp;Janina Bahnemann,&nbsp;Alexander Heisterkamp,&nbsp;Maria Leilani Torres-Mapa","doi":"10.1002/adpr.202400011","DOIUrl":null,"url":null,"abstract":"<p>Microfluidic lab-on-a-chip (LOC) devices have become essential tools for multitudes of applications in various research fields. 3D printing of microfluidic LOC devices offers many advantages over more traditional manufacturing processes, including rapid prototyping and single-step fabrication of complex 3D structures. In this work, 3D-printed microfluidic devices are designed and fabricated for optical chromatography and sorting. Optical chromatography is performed by inserting a single-mode optical fiber into the device creating a counter-propagating laser beam to the fluid flow. Particles are separated depending on refractive index and size. To demonstrate optical sorting, a cross-type sorter 3D-printed microfluidic device is fabricated that directs the laser beam perpendicular to the flow direction. Design features such as a sloping channel and a channel configuration for 3D hydrodynamic focusing (to aid in controlled sample flow and particle position) help to optimize sorting performance. Stable optofluidic trapping and sorting are successfully achieved using the fabricated microfluidic devices. These results highlight the tremendous potential of 3D printing of microfluidic LOC devices for applications aimed at the optofluidic manipulation of micron-sized particles.</p>","PeriodicalId":7263,"journal":{"name":"Advanced Photonics Research","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adpr.202400011","citationCount":"0","resultStr":"{\"title\":\"Design and Fabrication of 3D-Printed Lab-On-A-Chip Devices for Fiber-Based Optical Chromatography and Sorting\",\"authors\":\"Ole Milark,&nbsp;Marc Buttkewitz,&nbsp;Emil Agócs,&nbsp;Beate Legutko,&nbsp;Benjamin Bergmann,&nbsp;Janina Bahnemann,&nbsp;Alexander Heisterkamp,&nbsp;Maria Leilani Torres-Mapa\",\"doi\":\"10.1002/adpr.202400011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Microfluidic lab-on-a-chip (LOC) devices have become essential tools for multitudes of applications in various research fields. 3D printing of microfluidic LOC devices offers many advantages over more traditional manufacturing processes, including rapid prototyping and single-step fabrication of complex 3D structures. In this work, 3D-printed microfluidic devices are designed and fabricated for optical chromatography and sorting. Optical chromatography is performed by inserting a single-mode optical fiber into the device creating a counter-propagating laser beam to the fluid flow. Particles are separated depending on refractive index and size. To demonstrate optical sorting, a cross-type sorter 3D-printed microfluidic device is fabricated that directs the laser beam perpendicular to the flow direction. Design features such as a sloping channel and a channel configuration for 3D hydrodynamic focusing (to aid in controlled sample flow and particle position) help to optimize sorting performance. Stable optofluidic trapping and sorting are successfully achieved using the fabricated microfluidic devices. These results highlight the tremendous potential of 3D printing of microfluidic LOC devices for applications aimed at the optofluidic manipulation of micron-sized particles.</p>\",\"PeriodicalId\":7263,\"journal\":{\"name\":\"Advanced Photonics Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adpr.202400011\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Photonics Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adpr.202400011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Photonics Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adpr.202400011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

微流控芯片实验室(LOC)设备已成为各研究领域众多应用的重要工具。与传统制造工艺相比,三维打印微流控芯片设备具有许多优势,包括快速原型设计和复杂三维结构的单步制造。在这项工作中,我们设计并制造了用于光学色谱和分拣的三维打印微流控设备。光学色谱法是通过将单模光纤插入设备,在流体流动中产生一束反向传播的激光束来实现的。颗粒根据折射率和大小进行分离。为了演示光学分拣,我们制作了一个交叉型分拣机 3D 打印微流控装置,该装置可将激光束垂直于流动方向。倾斜通道和三维流体动力聚焦通道配置(有助于控制样品流和颗粒位置)等设计特点有助于优化分拣性能。利用制造的微流体设备成功实现了稳定的光流体捕获和分拣。这些结果凸显了三维打印微流体 LOC 设备在微米级颗粒光流体操纵应用中的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design and Fabrication of 3D-Printed Lab-On-A-Chip Devices for Fiber-Based Optical Chromatography and Sorting

Design and Fabrication of 3D-Printed Lab-On-A-Chip Devices for Fiber-Based Optical Chromatography and Sorting

Microfluidic lab-on-a-chip (LOC) devices have become essential tools for multitudes of applications in various research fields. 3D printing of microfluidic LOC devices offers many advantages over more traditional manufacturing processes, including rapid prototyping and single-step fabrication of complex 3D structures. In this work, 3D-printed microfluidic devices are designed and fabricated for optical chromatography and sorting. Optical chromatography is performed by inserting a single-mode optical fiber into the device creating a counter-propagating laser beam to the fluid flow. Particles are separated depending on refractive index and size. To demonstrate optical sorting, a cross-type sorter 3D-printed microfluidic device is fabricated that directs the laser beam perpendicular to the flow direction. Design features such as a sloping channel and a channel configuration for 3D hydrodynamic focusing (to aid in controlled sample flow and particle position) help to optimize sorting performance. Stable optofluidic trapping and sorting are successfully achieved using the fabricated microfluidic devices. These results highlight the tremendous potential of 3D printing of microfluidic LOC devices for applications aimed at the optofluidic manipulation of micron-sized particles.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
2.70%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信