Ole Milark, Marc Buttkewitz, Emil Agócs, Beate Legutko, Benjamin Bergmann, Janina Bahnemann, Alexander Heisterkamp, Maria Leilani Torres-Mapa
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引用次数: 0
摘要
微流控芯片实验室(LOC)设备已成为各研究领域众多应用的重要工具。与传统制造工艺相比,三维打印微流控芯片设备具有许多优势,包括快速原型设计和复杂三维结构的单步制造。在这项工作中,我们设计并制造了用于光学色谱和分拣的三维打印微流控设备。光学色谱法是通过将单模光纤插入设备,在流体流动中产生一束反向传播的激光束来实现的。颗粒根据折射率和大小进行分离。为了演示光学分拣,我们制作了一个交叉型分拣机 3D 打印微流控装置,该装置可将激光束垂直于流动方向。倾斜通道和三维流体动力聚焦通道配置(有助于控制样品流和颗粒位置)等设计特点有助于优化分拣性能。利用制造的微流体设备成功实现了稳定的光流体捕获和分拣。这些结果凸显了三维打印微流体 LOC 设备在微米级颗粒光流体操纵应用中的巨大潜力。
Design and Fabrication of 3D-Printed Lab-On-A-Chip Devices for Fiber-Based Optical Chromatography and Sorting
Microfluidic lab-on-a-chip (LOC) devices have become essential tools for multitudes of applications in various research fields. 3D printing of microfluidic LOC devices offers many advantages over more traditional manufacturing processes, including rapid prototyping and single-step fabrication of complex 3D structures. In this work, 3D-printed microfluidic devices are designed and fabricated for optical chromatography and sorting. Optical chromatography is performed by inserting a single-mode optical fiber into the device creating a counter-propagating laser beam to the fluid flow. Particles are separated depending on refractive index and size. To demonstrate optical sorting, a cross-type sorter 3D-printed microfluidic device is fabricated that directs the laser beam perpendicular to the flow direction. Design features such as a sloping channel and a channel configuration for 3D hydrodynamic focusing (to aid in controlled sample flow and particle position) help to optimize sorting performance. Stable optofluidic trapping and sorting are successfully achieved using the fabricated microfluidic devices. These results highlight the tremendous potential of 3D printing of microfluidic LOC devices for applications aimed at the optofluidic manipulation of micron-sized particles.