增强碳青霉烯类药物在细菌生物膜中的抗菌活性的方法

Matthew A. Lamb, Sandra Wiedbrauk and Kathryn E. Fairfull-Smith
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引用次数: 0

摘要

碳青霉烯类抗生素是抗击细菌感染的关键抗生素,可同时针对革兰氏阳性菌和革兰氏阴性菌,药效非凡。这些抗生素是一组重要的 "最后手段 "抗生素的一部分,专门用于耐多药细菌引起的严重感染。然而,滥用碳青霉烯类抗生素会造成严重威胁,过度使用碳青霉烯类抗生素会加速抗生素耐药性的产生,从而危及这些救命药物的疗效。导致这一问题复杂化的另一个因素是生物膜的出现。这些复杂的微生物群落被包裹在聚合物基质中,导致严重感染的发生,给治疗带来挑战。本综述探讨了临床批准的不同碳青霉烯类药物的生物膜效力,深入研究了增强其抗生物膜活性的最新策略和给药系统。目的是为开发专门用于抗生物膜的更强效碳青霉烯类药物提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Approaches to enhance the antimicrobial activity of carbapenems within bacterial biofilms

Approaches to enhance the antimicrobial activity of carbapenems within bacterial biofilms

Carbapenems are crucial antibiotics in the battle against bacterial infections, targeting both Gram-positive and Gram-negative bacteria with exceptional potency. These antibiotics are part of a group of vital ‘last resort’ antibiotics, reserved for severe infections caused by multi-drug resistant bacteria. However, their misuse poses a significant threat and the overuse of carbapenems accelerates the development of antibiotic resistance, thereby jeopardizing the efficacy of these lifesaving drugs. Another contributing factor complicating this issue is the emergence of biofilms. These complex microbial communities are encased in a polymeric matrix and contribute to the onset of serious infections which are challenging to treat. This review explores the biofilm potency of different clinically approved carbapenems, delving into the latest strategies and delivery systems employed to augment their anti-biofilm activity. The goal is to provide valuable insights into the development of more potent carbapenems specifically tailored for combating biofilms.

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