乌克兰的维生素 D 缺乏症：多中心横断面研究

Global Epidemiology Pub Date : 2024-10-10 DOI:10.1016/j.gloepi.2024.100170

Sofiia Shatylo , Volodymyr Bogomaz , Oleksii Babych

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引用次数: 0

摘要

背景有关乌克兰人口维生素 D 状态的流行病学数据十分有限。方法这项多中心横断面研究共纳入 11462 名参与者：1530 名儿童，中位年龄为 10 岁（IQR 6-14），其中 56.21% 为女性；9932 名成年人，中位年龄为 36 岁（IQR 26-48），其中 78.72% 为女性。2021 年 1 月至 12 月期间，在基辅和基辅州采用化学发光免疫测定法（UniCel DxI 800 Access Immunoassay System，美国贝克曼库尔特公司）对血清 25- 羟维生素 D（25(OH)D）水平进行了一次测定。临界值为：维生素 D 缺乏，50 nmol/L；中度缺乏，25-<50 nmol/L；严重缺乏，25 nmol/L；维生素 D 不足，50-<75 nmol/L；维生素 D 充足，75-<250 nmol/L；最佳浓度，75-<125 nmol/L；水平升高，125-<250 nmol/L；中毒，≥250 nmol/L。结果所有参与者的 25（OH）D 水平中位数为 65.4 nmol/L（IQR 49.5-85.6），2.9% 的参与者严重缺乏维生素 D（95 % CI：2.6-3.2），23% 的参与者中度缺乏维生素 D（95 % CI：22-24），37% 的参与者维生素 D 不足（95 % CI：36-38）。我们在 1-2 岁儿童中未发现维生素 D 缺乏症，但该年龄组有 4.2% 的儿童（95% CI：1.4-9.6）出现维生素 D 中毒症状。在成年人（≥18 岁）中，维生素 D 缺乏症的发病率为 26 %（95 % CI：25-27）。

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Vitamin D deficiency in Ukraine: A multicentre cross-sectional study

Background

Available epidemiological data on vitamin D status in the Ukrainian population are limited.

Objective

The aim of this study is to investigate the prevalence of vitamin D deficiency in Ukraine.

Methods

This multicentre cross-sectional study included a total of 11,462 participants: 1530 children with a median age 10 years, (IQR 6–14) and 56.21 % of them were female; 9932 adults with a median age of 36 years (IQR 26–48) and 78.72 % of them were female. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured once by chemiluminescent immunoassay (UniCel DxI 800 Access Immunoassay System, Beckman Coulter Inc., USA) in the period of January–December 2021 in Kyiv and Kyiv Oblast. The cut-offs were: vitamin D deficiency, <50 nmol/L; moderate deficiency, 25–<50 nmol/L; severe deficiency, <25 nmol/L; vitamin D insufficiency, 50–<75 nmol/L; vitamin D sufficiency, 75–<250 nmol/L; optimal concentration, 75–<125 nmol/L; increased levels, 125–<250 nmol/L; and toxicity, ≥250 nmol/L.

Results

The median 25(OH)D level was 65.4 nmol/L (IQR 49.5–85.6) among all participants, severe vitamin D deficiency was recorded in 2.9 % of participants (95 % CI: 2.6–3.2), moderate deficiency in 23 % (95 % CI: 22–24), and vitamin D insufficiency in 37 % (95 % CI: 36–38).

Prevalence of vitamin D deficiency in group 1–17 years was 23.5 % (95 % CI: 21–26). We did not find vitamin D deficiency in children aged 1–2 years; however toxic levels were recorded in 4.2 % of the children in this age group (95 % CI: 1.4–9.6). Among the adults (≥18 years old), prevalence of vitamin D deficiency was 26 % (95 % CI: 25–27).