日本老年人的肌肉量及其与肌肉疏松症和肌肉决定因素的关系：文化健康研究

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2024-10-14 DOI:10.1016/j.arcmed.2024.103095

Abulaiti Abudurezake , Saori Kakehi , Futaba Umemura , Hideyoshi Kaga , Yuki Someya , Hiroki Tabata , Yasuyo Yoshizawa , Hitoshi Naito , Tsubasa Tajima , Naoaki Ito , Hikaru Otsuka , Huicong Shi , Mari Sugimoto , Shota Sakamoto , Yukiko Muroga , Hidetaka Wakabayashi , Ryuzo Kawamori , Hirotaka Watada , Yoshifumi Tamura

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引用次数: 0

摘要

目的在高危老年人群中，肌肉疏松症会导致颌下肌肉（MM）厚度减少。方法在一项针对 1484 名东京老年人的横断面研究中，我们使用三维磁共振成像扫描评估了肌肉体积、骨骼肌质量（ASMM）、握力、饮食摄入量、吸烟、胰岛素样生长因子 1（IGF-1）水平和 ACTN3 R577X 多态性。结果我们研究的参与者平均年龄为（73.0 ± 5.3）岁，男性的MMV（男性：35.3 ± 7.8 mL，女性：25.0 ± 5.1 mL）明显高于女性。观察发现，MMV 与肌肉疏松症之间存在明显联系，在男女中，最低五分位数（Q1）与最高五分位数（Q5）相比风险更高。体重指数（BMI）和年龄是男女性肌肉萎缩症的独立决定因素，而体重指数则是肌肉萎缩症的决定因素，但有趣的是，体重指数与年龄无关。此外，IGF-1与男女的MMV呈正相关；吸烟与女性的MMV呈负相关。ACTN3 577XX 基因型只与男性较小的 MMV 有关。体重指数和年龄对 ASMM 有很大影响，而 MMV 与体重指数的关系较弱，与年龄的关系不大。值得注意的是，IGF-1 水平仅与 MMV 呈正相关，而 ACTN3 基因型仅与男性 MMV 减少相关。

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Masseter Muscle Volume and Its Association with Sarcopenia and Muscle Determinants in Older Japanese Adults: the Bunkyo Health Study

Aim

Sarcopenia has been with a decrease in masseter muscle (MM) thickness in high-risk older populations. However, the relationship between sarcopenia and determinants of MM volume (MMV) in the general elderly population remains unclear.

Method

In a cross-sectional study of 1,484 older adults in Tokyo, we evaluated MMV using 3D MRI scanning, appendicular skeletal muscle mass (ASMM), handgrip strength, dietary intake, smoking, insulin-like growth factor 1 (IGF-1) levels, and the ACTN3 R577X polymorphism. Participants were divided into quintiles based on MMV (Q1–5).

Results

Participants in our study had a mean age of 73.0 ± 5.3 years and their MMV (Men: 35.3 ± 7.8 mL, Women: 25.0 ± 5.1 mL) was significantly higher in men than in women. A significant association between MMV and sarcopenia was observed, with the lowest quintile (Q1) showing a higher risk compared to the highest quintile (Q5) in both sexes. Body mass index (BMI) and age were independent determinants of ASMM in both sexes, whereas BMI, but interestingly not age, was a determinant of MMV. Moreover, IGF-1 was positively correlated with MMV in both sexes; smoking was negatively correlated with MMV in women. The ACTN3 577XX genotype was only associated with smaller MMV in men.

Conclusion

Low MMV increased the risk of sarcopenia, particularly in men. BMI and age strongly influenced ASMM, while MMV was only weakly associated with BMI and not with age. Notably, IGF-1 level was positively associated with MMV only, and ACTN3 genotype was associated to reduced MMV only in men.

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.