{"title":"含有富氧空位 WOx 的多功能水凝胶用于协同光催化氧气生产和光热疗法,促进细菌感染的糖尿病伤口愈合","authors":"Xichen Sun, Pengfei Wang, Liuyan Tang, Ningning Li, Yan-Ru Lou, Yuezhou Zhang, Peng Li","doi":"10.1002/adfm.202411117","DOIUrl":null,"url":null,"abstract":"An effective method capable of simultaneously providing antibacterial activity, blood glucose regulation, and angiogenesis promotion for healing bacteria-infected diabetic wounds is not reported to date, but urgently required. In this study, a hydrogel composite (<i>γ</i>-PGA/PDA/GOx/WO<i><sub>x</sub></i> (PPGW)), endowed with these desired attributes is fabricated by incorporating polydopamine (PDA), glucose oxidase (GOx), and tungsten oxide (WO<i><sub>x</sub></i>) nanowires into the poly(<i>γ</i>-glutamic acid) (<i>γ</i>-PGA) framework. The exceptional photothermal conversion properties of PDA facilitated notable antibacterial effects on bacteria-infected diabetic wounds; GOx regulated high blood glucose by consuming glucose and generating hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>); while WO<i><sub>x</sub></i> nanowires displayed remarkable photocatalytic abilities, converting H<sub>2</sub>O<sub>2</sub> into oxygen (O<sub>2</sub>) when exposed to 808-nm near-infrared radiation. Density functional theory calculations and experiments are conducted to confirm the mechanism of WO<i><sub>x</sub></i>-mediated photocatalytic degradation of H<sub>2</sub>O<sub>2</sub> to produce O<sub>2</sub>. These transformations aided in alleviating the hypoxic conditions in wounds associated with diabetes, expediting angiogenesis, and fostering cell crawling and proliferation. Consequently, the multifunctional hydrogel dressing PPGW, featuring photothermal, antibacterial, and enzyme-catalyzed activity reduces hyperglycemia at the wound site. Moreover, photocatalytic O<sub>2</sub> production represents a promising strategy for addressing chronic bacteria-infected diabetic wounds.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifunctional Hydrogel Containing Oxygen Vacancy-Rich WOx for Synergistic Photocatalytic O2 Production and Photothermal Therapy Promoting Bacteria-Infected Diabetic Wound Healing\",\"authors\":\"Xichen Sun, Pengfei Wang, Liuyan Tang, Ningning Li, Yan-Ru Lou, Yuezhou Zhang, Peng Li\",\"doi\":\"10.1002/adfm.202411117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An effective method capable of simultaneously providing antibacterial activity, blood glucose regulation, and angiogenesis promotion for healing bacteria-infected diabetic wounds is not reported to date, but urgently required. In this study, a hydrogel composite (<i>γ</i>-PGA/PDA/GOx/WO<i><sub>x</sub></i> (PPGW)), endowed with these desired attributes is fabricated by incorporating polydopamine (PDA), glucose oxidase (GOx), and tungsten oxide (WO<i><sub>x</sub></i>) nanowires into the poly(<i>γ</i>-glutamic acid) (<i>γ</i>-PGA) framework. The exceptional photothermal conversion properties of PDA facilitated notable antibacterial effects on bacteria-infected diabetic wounds; GOx regulated high blood glucose by consuming glucose and generating hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>); while WO<i><sub>x</sub></i> nanowires displayed remarkable photocatalytic abilities, converting H<sub>2</sub>O<sub>2</sub> into oxygen (O<sub>2</sub>) when exposed to 808-nm near-infrared radiation. Density functional theory calculations and experiments are conducted to confirm the mechanism of WO<i><sub>x</sub></i>-mediated photocatalytic degradation of H<sub>2</sub>O<sub>2</sub> to produce O<sub>2</sub>. These transformations aided in alleviating the hypoxic conditions in wounds associated with diabetes, expediting angiogenesis, and fostering cell crawling and proliferation. Consequently, the multifunctional hydrogel dressing PPGW, featuring photothermal, antibacterial, and enzyme-catalyzed activity reduces hyperglycemia at the wound site. Moreover, photocatalytic O<sub>2</sub> production represents a promising strategy for addressing chronic bacteria-infected diabetic wounds.\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/adfm.202411117\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adfm.202411117","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Multifunctional Hydrogel Containing Oxygen Vacancy-Rich WOx for Synergistic Photocatalytic O2 Production and Photothermal Therapy Promoting Bacteria-Infected Diabetic Wound Healing
An effective method capable of simultaneously providing antibacterial activity, blood glucose regulation, and angiogenesis promotion for healing bacteria-infected diabetic wounds is not reported to date, but urgently required. In this study, a hydrogel composite (γ-PGA/PDA/GOx/WOx (PPGW)), endowed with these desired attributes is fabricated by incorporating polydopamine (PDA), glucose oxidase (GOx), and tungsten oxide (WOx) nanowires into the poly(γ-glutamic acid) (γ-PGA) framework. The exceptional photothermal conversion properties of PDA facilitated notable antibacterial effects on bacteria-infected diabetic wounds; GOx regulated high blood glucose by consuming glucose and generating hydrogen peroxide (H2O2); while WOx nanowires displayed remarkable photocatalytic abilities, converting H2O2 into oxygen (O2) when exposed to 808-nm near-infrared radiation. Density functional theory calculations and experiments are conducted to confirm the mechanism of WOx-mediated photocatalytic degradation of H2O2 to produce O2. These transformations aided in alleviating the hypoxic conditions in wounds associated with diabetes, expediting angiogenesis, and fostering cell crawling and proliferation. Consequently, the multifunctional hydrogel dressing PPGW, featuring photothermal, antibacterial, and enzyme-catalyzed activity reduces hyperglycemia at the wound site. Moreover, photocatalytic O2 production represents a promising strategy for addressing chronic bacteria-infected diabetic wounds.
期刊介绍:
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
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