{"title":"拟南芥根中控制免疫力的 FERONIA 的调节性裂解和转运","authors":"Jia Chen, Fan Xu, Xiaonan Qiang, Hongbin Liu, Long Wang, Lingli Jiang, Chiyu Li, Bingqian Wang, Sheng Luan, Dousheng Wu, Feng Zhou, Feng Yu","doi":"10.1038/s41477-024-01823-8","DOIUrl":null,"url":null,"abstract":"Plant roots exhibit localized immunity (LI) mainly in the transition zone (TZ) and elongation zone (EZ). Plasma membrane-localized receptor-like kinases (RLKs) can mediate the plant’s response to rhizosphere bacteria. However, how RLKs are involved in triggering LI in roots remains unclear. Here we identified dual actions for the RLK FERONIA (FER) in the LI response of Arabidopsis (Arabidopsis thaliana). The FER cytoplasmic domain is cleaved and translocated to the nucleus (FERN) to activate LI in the TZ and EZ in response to colonization by beneficial and pathogenic bacteria. In the absence or cessation of bacterial infection, full-length FER is plasma membrane-localized to maintain growth. Upon colonization and invasion by a high titre of bacteria, mature RAPID ALKALINIZATION FACTOR23 peptide accumulates and activates the matrix metalloproteinase At2-MMP, which triggers FER cytoplasmic domain cleavage specifically in the TZ and EZ to activate LI. This work demonstrates that two molecular forms of a single RLK balance growth and immunity via LI activation in Arabidopsis roots. This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 11","pages":"1761-1774"},"PeriodicalIF":15.8000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Regulated cleavage and translocation of FERONIA control immunity in Arabidopsis roots\",\"authors\":\"Jia Chen, Fan Xu, Xiaonan Qiang, Hongbin Liu, Long Wang, Lingli Jiang, Chiyu Li, Bingqian Wang, Sheng Luan, Dousheng Wu, Feng Zhou, Feng Yu\",\"doi\":\"10.1038/s41477-024-01823-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Plant roots exhibit localized immunity (LI) mainly in the transition zone (TZ) and elongation zone (EZ). Plasma membrane-localized receptor-like kinases (RLKs) can mediate the plant’s response to rhizosphere bacteria. However, how RLKs are involved in triggering LI in roots remains unclear. Here we identified dual actions for the RLK FERONIA (FER) in the LI response of Arabidopsis (Arabidopsis thaliana). The FER cytoplasmic domain is cleaved and translocated to the nucleus (FERN) to activate LI in the TZ and EZ in response to colonization by beneficial and pathogenic bacteria. In the absence or cessation of bacterial infection, full-length FER is plasma membrane-localized to maintain growth. Upon colonization and invasion by a high titre of bacteria, mature RAPID ALKALINIZATION FACTOR23 peptide accumulates and activates the matrix metalloproteinase At2-MMP, which triggers FER cytoplasmic domain cleavage specifically in the TZ and EZ to activate LI. This work demonstrates that two molecular forms of a single RLK balance growth and immunity via LI activation in Arabidopsis roots. This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.\",\"PeriodicalId\":18904,\"journal\":{\"name\":\"Nature Plants\",\"volume\":\"10 11\",\"pages\":\"1761-1774\"},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Plants\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41477-024-01823-8\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41477-024-01823-8","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
植物根系主要在过渡区(TZ)和伸长区(EZ)表现出局部免疫(LI)。质膜定位的类受体激酶(RLKs)可以介导植物对根瘤菌的反应。然而,RLKs 是如何参与触发根部 LI 的仍不清楚。在这里,我们发现了 RLK FERONIA(FER)在拟南芥(Arabidopsis thaliana)根瘤菌反应中的双重作用。FER 细胞质结构域被裂解并转运到细胞核(FERN),以激活 TZ 和 EZ 中的 LI,从而对有益菌和病原菌的定殖做出反应。在没有细菌感染或细菌感染停止时,全长 FER 定位于质膜,以维持生长。当高滴度细菌定植和入侵时,成熟的 RAPID ALKALINIZATION FACTOR23 肽积累并激活基质金属蛋白酶 At2-MMP,从而引发 FER 细胞质结构域特异性地在 TZ 和 EZ 中裂解,激活 LI。这项工作证明,单一 RLK 的两种分子形式通过拟南芥根中的 LI 激活来平衡生长和免疫。
Regulated cleavage and translocation of FERONIA control immunity in Arabidopsis roots
Plant roots exhibit localized immunity (LI) mainly in the transition zone (TZ) and elongation zone (EZ). Plasma membrane-localized receptor-like kinases (RLKs) can mediate the plant’s response to rhizosphere bacteria. However, how RLKs are involved in triggering LI in roots remains unclear. Here we identified dual actions for the RLK FERONIA (FER) in the LI response of Arabidopsis (Arabidopsis thaliana). The FER cytoplasmic domain is cleaved and translocated to the nucleus (FERN) to activate LI in the TZ and EZ in response to colonization by beneficial and pathogenic bacteria. In the absence or cessation of bacterial infection, full-length FER is plasma membrane-localized to maintain growth. Upon colonization and invasion by a high titre of bacteria, mature RAPID ALKALINIZATION FACTOR23 peptide accumulates and activates the matrix metalloproteinase At2-MMP, which triggers FER cytoplasmic domain cleavage specifically in the TZ and EZ to activate LI. This work demonstrates that two molecular forms of a single RLK balance growth and immunity via LI activation in Arabidopsis roots. This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.
期刊介绍:
Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.