Cu-Catalyzed Coupling of Sulfonyl Chlorides with Alkenes: Synthesis of Dienyl Sulfones and β-Chlorosulfones

This work reports a Cu-catalyzed coupling technique for synthesizing (E)-dienyl sulfones and β-chlorosulfones from 1-arylbutadienes and styrenes, respectively. By employing easily available and inexpensive reagents, this method enables the synthesis of a diverse array of dienyl sulfones and β-chlorosulfones with excellent functional group tolerance under base- and oxidant-free conditions. It also proves versatile for the late-stage functionalization of drug molecules and the scale-up reactions. The method showcases notable selectivity, gentle reaction conditions, and compatibility with various functional groups as demonstrated through 66 examples with excellent display of regioselectivity.