与二硫化硫相关的基因可作为个性化治疗的目标并有助于预后分析

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Annette Fenner
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引用次数: 0

摘要

二硫化硫是前列腺癌的一种程序性细胞死亡途径。发表在《科学报告》上的一项研究调查了与二硫化硫相关的基因在疾病发病和进展中的作用。研究小组建立了一个风险评分模型,然后研究了该评分与免疫特征、体细胞突变和治疗反应之间的关系。研究发现了两种二硫化血症亚型:根据风险评分,高风险组的无进展生存期较差,肿瘤突变负荷较高,与免疫抑制增加有关;这些高风险特征与包括IL-17信号在内的癌症通路有关。药物敏感性分析表明,由于化疗反应各不相同,基于二硫化物的个性化治疗策略具有潜力。PROK1 被确定为预后标志物,其表达减少与疾病进展相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disulfidptosis-related genes could target personalized therapy and aid prognostics
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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