使用 R-22 气体对异质原子进行快速（氚）二氟甲基化反应：流动化学在抑制内在反应途径方面的示范。

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-10-14 DOI:10.1002/adsc.202401083

Hon Cheung Leung, Tsz Chun Lee, Wing-Tak Wong, Wai Chung Fu

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引用次数: 0

摘要

封面是一张塔罗牌，名为 "流"。一位圣人坐在溪流边（象征流动系统），手持氘和氢原子，决定着天空中 ClCF2H 分子的反应路径。通过改变流动系统中的添加和混合顺序，ClCF2H 气体可以与杂原子阴离子发生 SN2 反应，生成 X-CF2H 产物，或者选择性地转化为二氟羰基，进行基于碳的片段耦合，生成 X-CF2D 产物。更多详情可参阅傅伟忠及其合作者的通讯（H. C. Leung, T. C. Lee, W.-T. Wong, W. C. Fu, 2009）。Wong, W. C. Fu, Adv.Catal.2024, 366, XXXX-XXXX; DOI: 10.1002/adsc.202400826)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rapid (Deuterio)difluoromethylation of Heteroatoms Using R-22 Gas: A Demonstration of Flow Chemistry in Suppressing Intrinsic Reaction Pathways.

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Rapid (Deuterio)difluoromethylation of Heteroatoms Using R-22 Gas: A Demonstration of Flow Chemistry in Suppressing Intrinsic Reaction Pathways.

The front cover features a Tarot-style card titled “THE FLOW”. A sage seated by a cascading stream (symbolizing a flow system) holds deuterium and hydrogen atoms and determines the reaction pathway for ClCF₂H molecules in the sky. By varying the addition and mixing sequences within a flow system, ClCF₂H gas can undergo an SN2 reaction with heteroatom anions to produce X-CF₂H products, or be selectively converted into difluorocarbenes for a carbene-based fragment coupling, yielding X-CF₂D products. More details can be found in Communication by Wai Chung Fu and co-workers (H. C. Leung, T. C. Lee, W.-T. Wong, W. C. Fu, Adv. Synth. Catal. 2024, 366, XXXX–XXXX; DOI: 10.1002/adsc.202400826)

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.