优化磷酸盐玻璃陶瓷中的锰锌铁氧体掺杂，提高热疗效率和生物活性

IF 44 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

The Lancet Diabetes & Endocrinology Pub Date : 2024-10-11 DOI:10.1016/j.ceramint.2024.10.146

Pratthana Intawin, Arnon Kraipok, Naris Barnthip, Puripat Kantha, Ruamporn Potong, Surapong Panyata, Sukum Eitssayeam, Kamonpan Pengpat

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引用次数: 0

摘要

本研究探讨了锰锌铁氧体（MZF）含量和热处理温度对 Na2O-CaO-P2O5 玻璃陶瓷的结构、机械、磁性和生物活性特性的影响。在玻璃陶瓷中加入不同含量的 MZF（5MZF、10MZF、20MZF 和 40MZF），并在不同温度（600、650、700 和 800°C）下进行热处理。结果表明，增加 MZF 含量可显著提高机械性能，包括维氏硬度、努氏硬度和杨氏模量。例如，维氏硬度值从 5MZF 样品的 5.6 GPa 增加到 40MZF 样品的 7.1 GPa。X 射线衍射分析显示了主要结晶相的存在，如 Ca2P2O7 和 Na4Ca(PO3)6，而 NaFe3P3O12 和 (Zn,Mn)Fe2O4 则出现在 MZF 含量较高的样品中。磁性测量结果表明，在 700°C 温度下处理的 40MZF 样品在 16 分钟内达到了令人满意的 43°C 高热温度。生物活性测试表明，生物活性随着 MZF 含量的增加而降低，而细胞毒性测试则证实，所有 MZF-Na2O-CaO-P2O5 生物活性玻璃陶瓷都是无毒的，24 小时后细胞存活率保持在 100%以上。

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Optimization of Mn-Zn Ferrite Doping in Phosphate-Based Glass Ceramics for Enhanced Hyperthermia Efficiency and Bioactivity

This study investigates the effects of Mn-Zn ferrite (MZF) content and heat treatment temperature on the structural, mechanical, magnetic, and bioactive properties of Na₂O-CaO-P₂O₅ glass ceramics. Various MZF contents (5MZF, 10MZF, 20MZF, and 40MZF) were incorporated into the glass ceramics and subjected to heat treatment at different temperatures (600, 650, 700, and 800°C). The results demonstrated that increasing the MZF content significantly enhanced the mechanical properties, including Vickers hardness, Knoop hardness, and Young's modulus. For example, the Vickers hardness values increased from 5.6 GPa in 5MZF samples to 7.1 GPa in 40MZF samples. X-ray diffraction analysis revealed the presence of major crystalline phases, such as Ca₂P₂O₇ and Na₄Ca(PO₃)₆, with NaFe₃P₃O₁₂ and (Zn,Mn)Fe₂O₄ appearing in samples with higher MZF content. Magnetic measurements indicated that the 40MZF samples treated at 700°C reached a satisfactory hyperthermia temperature of 43°C within 16 min. Bioactivity tests showed a decrease in bioactivity with increasing MZF content, whereas cytotoxicity assays confirmed that all MZF-Na₂O-CaO-P₂O₅ bioactive glass ceramics were non-toxic, maintaining over 100% cell viability after 24 h. These findings suggest that MZF-containing glass ceramics have potential applications in the biomedical field, particularly when enhanced mechanical and magnetic properties are required.

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来源期刊

The Lancet Diabetes & Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

61.50

自引率

1.60%

发文量

371

期刊介绍： The Lancet Diabetes & Endocrinology, an independent journal with a global perspective and strong clinical focus, features original clinical research, expert reviews, news, and opinion pieces in each monthly issue. Covering topics like diabetes, obesity, nutrition, and more, the journal provides insights into clinical advances and practice-changing research worldwide. It welcomes original research advocating change or shedding light on clinical practice, as well as informative reviews on related topics, especially those with global health importance and relevance to low-income and middle-income countries. The journal publishes various content types, including Articles, Reviews, Comments, Correspondence, Health Policy, and Personal Views, along with Series and Commissions aiming to drive positive change in clinical practice and health policy in diabetes and endocrinology.