{"title":"优化磷酸盐玻璃陶瓷中的锰锌铁氧体掺杂,提高热疗效率和生物活性","authors":"Pratthana Intawin , Arnon Kraipok , Naris Barnthip , Puripat Kantha , Ruamporn Potong , Surapong Panyata , Sukum Eitssayeam , Kamonpan Pengpat","doi":"10.1016/j.ceramint.2024.10.146","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the effects of Mn-Zn ferrite (MZF) content and heat treatment temperature on the structural, mechanical, magnetic, and bioactive properties of Na<sub>2</sub>O-CaO-P<sub>2</sub>O<sub>5</sub> glass ceramics. Various MZF contents (5MZF, 10MZF, 20MZF, and 40MZF) were incorporated into the glass ceramics and subjected to heat treatment at different temperatures (600, 650, 700, and 800 °C). The results demonstrated that increasing the MZF content significantly enhanced the mechanical properties, including Vickers hardness, Knoop hardness, and Young's modulus. For example, the Vickers hardness values increased from 5.6 GPa in 5MZF samples to 7.1 GPa in 40MZF samples. X-ray diffraction analysis revealed the presence of major crystalline phases, such as Ca<sub>2</sub>P<sub>2</sub>O<sub>7</sub> and Na<sub>4</sub>Ca(PO<sub>3</sub>)<sub>6</sub>, with NaFe<sub>3</sub>P<sub>3</sub>O<sub>12</sub> and (Zn,Mn)Fe<sub>2</sub>O<sub>4</sub> appearing in samples with higher MZF content. Magnetic measurements indicated that the 40MZF samples treated at 700 °C reached a satisfactory hyperthermia temperature of 43 °C within 16 min. Bioactivity tests showed a decrease in bioactivity with increasing MZF content, whereas cytotoxicity assays confirmed that all MZF-Na<sub>2</sub>O-CaO-P<sub>2</sub>O<sub>5</sub> bioactive glass ceramics were non-toxic, maintaining over 100 % cell viability after 24 h. These findings suggest that MZF-containing glass ceramics have potential applications in the biomedical field, particularly when enhanced mechanical and magnetic properties are required.</div></div>","PeriodicalId":267,"journal":{"name":"Ceramics International","volume":"50 24","pages":"Pages 52957-52966"},"PeriodicalIF":5.1000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimization of Mn-Zn ferrite doping in phosphate-based glass ceramics for enhanced hyperthermia efficiency and bioactivity\",\"authors\":\"Pratthana Intawin , Arnon Kraipok , Naris Barnthip , Puripat Kantha , Ruamporn Potong , Surapong Panyata , Sukum Eitssayeam , Kamonpan Pengpat\",\"doi\":\"10.1016/j.ceramint.2024.10.146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study investigates the effects of Mn-Zn ferrite (MZF) content and heat treatment temperature on the structural, mechanical, magnetic, and bioactive properties of Na<sub>2</sub>O-CaO-P<sub>2</sub>O<sub>5</sub> glass ceramics. Various MZF contents (5MZF, 10MZF, 20MZF, and 40MZF) were incorporated into the glass ceramics and subjected to heat treatment at different temperatures (600, 650, 700, and 800 °C). The results demonstrated that increasing the MZF content significantly enhanced the mechanical properties, including Vickers hardness, Knoop hardness, and Young's modulus. For example, the Vickers hardness values increased from 5.6 GPa in 5MZF samples to 7.1 GPa in 40MZF samples. X-ray diffraction analysis revealed the presence of major crystalline phases, such as Ca<sub>2</sub>P<sub>2</sub>O<sub>7</sub> and Na<sub>4</sub>Ca(PO<sub>3</sub>)<sub>6</sub>, with NaFe<sub>3</sub>P<sub>3</sub>O<sub>12</sub> and (Zn,Mn)Fe<sub>2</sub>O<sub>4</sub> appearing in samples with higher MZF content. Magnetic measurements indicated that the 40MZF samples treated at 700 °C reached a satisfactory hyperthermia temperature of 43 °C within 16 min. Bioactivity tests showed a decrease in bioactivity with increasing MZF content, whereas cytotoxicity assays confirmed that all MZF-Na<sub>2</sub>O-CaO-P<sub>2</sub>O<sub>5</sub> bioactive glass ceramics were non-toxic, maintaining over 100 % cell viability after 24 h. These findings suggest that MZF-containing glass ceramics have potential applications in the biomedical field, particularly when enhanced mechanical and magnetic properties are required.</div></div>\",\"PeriodicalId\":267,\"journal\":{\"name\":\"Ceramics International\",\"volume\":\"50 24\",\"pages\":\"Pages 52957-52966\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2024-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ceramics International\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0272884224046583\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, CERAMICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceramics International","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0272884224046583","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, CERAMICS","Score":null,"Total":0}
Optimization of Mn-Zn ferrite doping in phosphate-based glass ceramics for enhanced hyperthermia efficiency and bioactivity
This study investigates the effects of Mn-Zn ferrite (MZF) content and heat treatment temperature on the structural, mechanical, magnetic, and bioactive properties of Na2O-CaO-P2O5 glass ceramics. Various MZF contents (5MZF, 10MZF, 20MZF, and 40MZF) were incorporated into the glass ceramics and subjected to heat treatment at different temperatures (600, 650, 700, and 800 °C). The results demonstrated that increasing the MZF content significantly enhanced the mechanical properties, including Vickers hardness, Knoop hardness, and Young's modulus. For example, the Vickers hardness values increased from 5.6 GPa in 5MZF samples to 7.1 GPa in 40MZF samples. X-ray diffraction analysis revealed the presence of major crystalline phases, such as Ca2P2O7 and Na4Ca(PO3)6, with NaFe3P3O12 and (Zn,Mn)Fe2O4 appearing in samples with higher MZF content. Magnetic measurements indicated that the 40MZF samples treated at 700 °C reached a satisfactory hyperthermia temperature of 43 °C within 16 min. Bioactivity tests showed a decrease in bioactivity with increasing MZF content, whereas cytotoxicity assays confirmed that all MZF-Na2O-CaO-P2O5 bioactive glass ceramics were non-toxic, maintaining over 100 % cell viability after 24 h. These findings suggest that MZF-containing glass ceramics have potential applications in the biomedical field, particularly when enhanced mechanical and magnetic properties are required.
期刊介绍:
Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties.
Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour.
Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.