蓝莓提取物可通过调节 Akt 通路减轻去神经骨骼肌萎缩过程中 Cx43 的负面影响

IF 3.5 2区 农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xinying Huang, Jibo Liu, Junpeng Zhang, Zongqi You, Yaoxian Xiang, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang Xu
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引用次数: 0

摘要

缺乏有效的治疗方法来缓解由周围神经功能障碍引起的不可逆转的骨骼肌萎缩是一个临床问题。为了确定治疗靶点,人们探索了因神经支配而激活的肌肉细胞信号通路,包括 Cx43(一种形成间隙连接的蛋白质)在其他类型病理过程中的重要作用。本研究探讨了 Cx43 在去神经支配后加重肌肉细胞变性中的负面作用。通过湿重测量和组织染色观察,发现蓝莓提取物对去神经化骨骼肌萎缩有保护作用。蓝莓提取物调节了去神经肌肉细胞中的 Cx43/Akt 通路。总之,蓝莓提取物通过调节Akt通路减轻了Cx43对去神经骨骼肌萎缩的负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy Can Be Attenuated by Blueberry Extracts via Regulating Akt Pathway

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy Can Be Attenuated by Blueberry Extracts via Regulating Akt Pathway

The lack of effective treatments for alleviating irreversible skeletal muscle atrophy caused by peripheral nerve dysfunction is a clinical problem. To identify therapeutic targets, signaling pathways in muscle cells activated by denervation have been explored, including the important roles of Cx43, a kind of protein that forms gap junctions, in other types of pathological process. The present study investigated the negative role of Cx43 in aggravated muscle cell degeneration following denervation. The blueberry extract was applied orally on mice models, and its protective effect against denervated skeletal muscle atrophy was found by wet weight measurement and tissue staining observation. Cx43/Akt pathway in denervated muscle cells was modulated by blueberry extract. In conclusion, the negative effects of Cx43 on denervated skeletal muscle atrophy were attenuated by blueberry extract by regulating the Akt pathway.

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来源期刊
Journal of Food Biochemistry
Journal of Food Biochemistry 生物-生化与分子生物学
CiteScore
7.80
自引率
5.00%
发文量
488
审稿时长
3.6 months
期刊介绍: The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality
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