住宅区暴露于交通噪声与心房颤动发病风险：11 项前瞻性北欧队列的汇总研究

IF 13.6 Q1 HEALTH CARE SCIENCES & SERVICES

Lancet Regional Health-Europe Pub Date : 2024-10-01 DOI:10.1016/j.lanepe.2024.101091

Jesse D. Thacher , Nina Roswall , Mikael Ögren , Andrei Pyko , Agneta Åkesson , Anna Oudin , Annika Rosengren , Aslak H. Poulsen , Charlotta Eriksson , David Segersson , Debora Rizzuto , Emilie Helte , Eva M. Andersson , Gunn Marit Aasvang , Gunnar Engström , Hrafnhildur Gudjonsdottir , Jenny Selander , Jesper H. Christensen , Jørgen Brandt , Karin Leander , Mette Sørensen

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引用次数: 0

摘要

背景交通噪声与心脏代谢结果有关，但它是否是心房颤动（房颤）的风险因素仍无定论。我们的目的是在一个大型的北欧队列中评估交通噪声是否与心房颤动有关。方法我们汇总了 11 个北欧队列的数据，共有 161,115 名参与者。根据基线前五年至随访结束期间的住址史，对住宅水平的公路、铁路和飞机噪声进行了估算。通过与全国范围内的患者登记处建立联系，确定了房颤的发病情况。在对社会人口统计学、生活方式和空气污染等因素进行调整后，利用 Cox 比例危险模型来估算 5 年时间加权平均交通噪声（Lden）与房颤之间的关系。道路交通噪声与心房颤动有关，每 10 分贝的 5 年平均时间加权暴露的危险比 (HR) 和 95% 置信区间 (CI) 为 1.02（1.00-1.04），当采用 53 分贝截止值时，危险比和 95% 置信区间变为 1.03（1.01-1.06）。在效应修正分析中，道路交通噪声与房颤的关联在女性、超重和肥胖参与者中似乎最强。与≤40 分贝的暴露值相比，40.1-50 分贝和 > 50 分贝的飞机噪声分别与 1.04（0.93-1.16）和 1.12（0.98-1.27）的心率相关。铁路噪声与房颤无关。我们发现，暴露于公路噪声（≥45 dB）、铁路噪声（>40 dB）和飞机噪声（>40 dB）的人群的心率为1.19（1.02-1.40）。

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Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts

Background

Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort.

Methods

We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (L_den) and AF after adjusting for sociodemographics, lifestyle, and air pollution.

Findings

We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined.

Interpretation

Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF.

Funding

NordForsk.

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来源期刊

Lancet Regional Health-Europe Multiple-

CiteScore

19.90

自引率

1.40%

发文量

260

审稿时长

9 weeks

期刊介绍： The Lancet Regional Health – Europe, a gold open access journal, is part of The Lancet's global effort to promote healthcare quality and accessibility worldwide. It focuses on advancing clinical practice and health policy in the European region to enhance health outcomes. The journal publishes high-quality original research advocating changes in clinical practice and health policy. It also includes reviews, commentaries, and opinion pieces on regional health topics, such as infection and disease prevention, healthy aging, and reducing health disparities.