{"title":"作为抗癌剂的 1,2,3-三唑芳基连接 (4,6 二甲基氧基-1,3,5-三嗪-2-基) 噻唑衍生物的合理设计、合成和生物学评价","authors":"Renuka Charugandla , Sridhar Chidara , Ashok Dasari , Somaiah Nalla , Raghu Babu Korupolu , S.K. Raziya , Kishore Babu Bonige","doi":"10.1016/j.rechem.2024.101806","DOIUrl":null,"url":null,"abstract":"<div><div>A new library of 1,2,3-triazole aryl-attached (4,6-dimethoxy-1,3,5-triazin-2-yl) thiazoles (<strong>11a–j</strong>) has been designed and synthesized and its structures were characterized by <sup>1</sup>H NMR <sup>13</sup>C NMR and mass spectral data. Further, these derivatives (<strong>11a-j</strong>) were evaluated for their anticancer activity against four human cancer cell lines, including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and A2780 (ovarian cancer) by employing the MTT method, and the obtained results were compared with etoposide. Among all the examined compounds, <strong>11a, 11b, 11c, 11i</strong> and <strong>11j</strong> displayed the most promising activity. Particularly, two compounds <strong>11a</strong> and <strong>11b</strong> possessed good activity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101806"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rational design, synthesis and biological evaluation 1,2,3-triazole aryl attached (4,6-dimethoxy-1,3,5-triazin-2-yl)thiazole derivatives as anticancer agents\",\"authors\":\"Renuka Charugandla , Sridhar Chidara , Ashok Dasari , Somaiah Nalla , Raghu Babu Korupolu , S.K. Raziya , Kishore Babu Bonige\",\"doi\":\"10.1016/j.rechem.2024.101806\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A new library of 1,2,3-triazole aryl-attached (4,6-dimethoxy-1,3,5-triazin-2-yl) thiazoles (<strong>11a–j</strong>) has been designed and synthesized and its structures were characterized by <sup>1</sup>H NMR <sup>13</sup>C NMR and mass spectral data. Further, these derivatives (<strong>11a-j</strong>) were evaluated for their anticancer activity against four human cancer cell lines, including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and A2780 (ovarian cancer) by employing the MTT method, and the obtained results were compared with etoposide. Among all the examined compounds, <strong>11a, 11b, 11c, 11i</strong> and <strong>11j</strong> displayed the most promising activity. Particularly, two compounds <strong>11a</strong> and <strong>11b</strong> possessed good activity.</div></div>\",\"PeriodicalId\":420,\"journal\":{\"name\":\"Results in Chemistry\",\"volume\":\"11 \",\"pages\":\"Article 101806\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Results in Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211715624005022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211715624005022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Rational design, synthesis and biological evaluation 1,2,3-triazole aryl attached (4,6-dimethoxy-1,3,5-triazin-2-yl)thiazole derivatives as anticancer agents
A new library of 1,2,3-triazole aryl-attached (4,6-dimethoxy-1,3,5-triazin-2-yl) thiazoles (11a–j) has been designed and synthesized and its structures were characterized by 1H NMR 13C NMR and mass spectral data. Further, these derivatives (11a-j) were evaluated for their anticancer activity against four human cancer cell lines, including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and A2780 (ovarian cancer) by employing the MTT method, and the obtained results were compared with etoposide. Among all the examined compounds, 11a, 11b, 11c, 11i and 11j displayed the most promising activity. Particularly, two compounds 11a and 11b possessed good activity.
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