南海软珊瑚中的大环消炎二萜及其柱层析分离方法

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
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引用次数: 0

摘要

利用组合柱层析法,从中国南海软珊瑚直立杉中分离出了 11 种新的大环壳牌二萜,即 sinueracasbanones E-O (1-11)。通过大量的光谱数据分析、改良莫舍尔法、X 射线衍射分析和量子力学计算方法,阐明了新化合物的结构。在生物测定中,化合物 2、5、10 和 11 通过抑制脂多糖(LPS)诱导的肿瘤坏死因子(TNF)-α 蛋白的释放而显示出有趣的抗炎活性,其半最大抑制浓度(IC50)值分别为 15.6、7.1、13.7 和 6.6 µM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography
Eleven new macrocyclic casbane-type diterpenes, namely sinueracasbanones E–O (111), have been isolated from the South China Sea soft coral Sinularia erecta using combined column chromatography. The structures of new compounds were elucidated by extensive spectroscopic data analysis, the modified Mosher's method, X-ray diffraction analysis and quantum mechanical calculation methods. In bioassay, compounds 2, 5, 10 and 11 displayed interesting anti-inflammatory activities by the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α protein release with half maximal inhibitory concentration (IC50) values of 15.6, 7.1, 13.7 and 6.6 µM, respectively.
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来源期刊
Journal of Chromatography A
Journal of Chromatography A 化学-分析化学
CiteScore
7.90
自引率
14.60%
发文量
742
审稿时长
45 days
期刊介绍: The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.
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