氦诱导 DNA 损伤与质子诱导 DNA 损伤的蒙特卡罗模拟比较研究

IF 1.4 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms Pub Date : 2024-10-02 DOI:10.1016/j.nimb.2024.165538

Renjun Jin, Jie Ma, Hao Shen, Zhaohong Mi

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引用次数: 0

摘要

氦离子被认为是一种有效的放射治疗方法，而与氦离子的细胞效应相关的物理量表征对于开发和改进氦离子治疗计划系统非常重要。本研究利用 Geant4-DNA 获得了物理能量沉积和 OH 反应位点，为基于密度的带噪声应用空间聚类（DBSCAN）提供了数据，并获得了与 DNA 链断裂相关的物理量。计算结果与其他计算结果进行了比较，结果表明，如果变量选择得当，DBSCAN 可用来计算 DNA 损伤。化学过程的氦DSB（双股断裂）产量从LET为56.3 keV/μm时的11.48 (GyGbp)-1增加到219.2 keV/μm时的49.32 (GyGbp)-1。化学过程的氦 SSB（单链断裂）产量从 56.3 keV/μm LET 时的 255.36 (GyGbp)-1 降至 219.2 keV/μm 时的 161.28 (GyGbp)-1。与未经过化学处理的情况相比，氦粒子在肺腺癌细胞核上诱发的 SSB 和 DSB 数量分别增加了约 90% 和 200%。

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Comparative Monte Carlo simulation study of helium-induced DNA damage versus proton

Helium ions are thought to be effective for radiotherapy, and characterization of physical quantities related to cellular effects of helium ions are important in order to develop and improve treatment planning systems for helium ions. In this study, Geant4-DNA was used to obtain the physical energy deposit and OH reaction sites to feed the density-based spatial clustering of applications with noise (DBSCAN) and obtain the quantities related with DNA strand breaks. The results are compared to other calculations and show that with proper choice of variables, DBSCAN could be used to calculate the DNA damage. The helium DSB (double strand break) yields with chemical processes increased from 11.48

{(G y G b p)}^{- 1}

with the LET of 56.3 keV/μm to 49.32

{(G y G b p)}^{- 1}

at 219.2 keV/μm. The helium SSB (single strand break) yields with chemical processes decreased from 255.36

{(G y G b p)}^{- 1}

with the LET of 56.3 keV/μm to 161.28

{(G y G b p)}^{- 1}

at 219.2 keV/μm. SSB and DSB counts induced by helium particles incident on the lung adenocarcinoma cell nucleus increased by about 90 % and 200 % compared with those without chemical processes.

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来源期刊

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms 物理-核科学技术

CiteScore

2.80

自引率

7.70%

发文量

231

审稿时长

1.9 months

期刊介绍： Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.