根据免疫生物标志物评估药用植物在治疗细菌感染方面的功效：现状与未来方向

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-10-05 DOI:10.1016/j.genrep.2024.102052

Joefred Mbogho Abogo , Cédric Sima Obiang , Herman Begouabe , Rick Léonid Ngoua Meye Misso , Juliette Ornely Orango Bourdette , Guy Roger Ndong Atome , Louis Clément Obame Engonga , Joseph Privat Ondo

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引用次数: 0

摘要

如今，各种感染性和非感染性疾病都可以用各种植物来治疗。本文旨在提供一个框架，利用炎症的免疫学指标（细胞因子）来评估和跟踪细菌感染的管理。因此，它展示了炎症标志物的产生、各种植物提取物对这些标志物的调节、这些植物提取物对引起细菌感染的各种细菌的消除，当然还有目前关于细菌感染的后果及其对抗生素的抗药性的报告。研究表明，植物提取物除了对多种细菌菌株具有抗菌功效外，还具有多种体内免疫调节作用。药用植物提取物在控制免疫系统基因表达方面的潜在功效使其成为诊断、管理和预防细菌感染的重要工具。本研究提出的观点需要利用现代科学技术方法进一步研究和完善。

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Evaluation of the efficacy of medicinal plants based on immunological biomarkers in the treatment of bacterial infections: Current status and future directions

Nowadays, a variety of infectious and non-infectious disorders are treated with various plants. This paper seeks to provide a framework for assessing and tracking the management of bacterial infections using immunological indicators of inflammation (cytokines). Thus, it demonstrates the production of inflammatory markers, the regulation of these markers by various plant extracts, the elimination of the various bacteria causing bacterial infections by these plant extracts, and, of course, a current report on the consequences of bacterial infections and their resistance to antibiotics. It has been demonstrated that plant extracts have a variety of immunomodulatory effects in vivo in addition to having antibacterial efficacy against multiple bacterial strains. The potential efficacy of medicinal plant extracts in controlling immune system gene expression makes them a vital tool for the diagnosis, management, and prevention of bacterial infections. The beliefs provided in this study need further investigation and refinement using modern scientific and technological methods.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.