了解Strongyloides Stercoralis感染及其与长期酗酒的关系:了解发病机制和治疗策略

Q1 Environmental Science
Rishvini Kailashnath Pillai , Roshvin Kailashnath Pillai , Vinibha Rajakumari Illankovan , Vinoth Kumarasamy , Satyanarayana Reddy , K. Gowtham , Muralikrishnan Dhanasekaran , Vetriselvan Subramaniyan
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引用次数: 0

摘要

在全球范围内,盘尾丝虫是一种流行的线虫寄生虫,感染人数超过 6 亿,主要分布在热带地区。尽管这种寄生虫广泛存在,但却经常被诊断不足和忽视,对健康构成重大威胁,尤其是对免疫力低下的人。这种寄生虫的生命周期包括令人担忧的自身感染能力,可能导致高死亡率的高感染综合征。由于酒精对免疫系统的有害影响,酗酒已被公认为是加重盘尾丝虫感染的一个主要风险因素。长期饮酒会降低 T 细胞和 B 细胞的功能,从而损害适应性免疫力,导致寄生虫感染。这篇综述探讨了酗酒与强直性脊柱炎之间的复杂关系,强调了其中涉及的分子机制。此外,还讨论了诊断难题和治疗方案,特别是伊维菌素等抗寄生虫药物的疗效。了解这些相互作用对于制定更好的诊断和治疗策略以防治强直性阿米巴病至关重要,尤其是在易感人群中,并强调了未来的研究领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding Strongyloides Stercoralis infection and its relationship to chronic alcohol abuse: Understanding pathogenesis and therapeutic strategies
Globally, Strongyloides stercoralis is a prevalent nematode parasite infecting over 600 million individuals, predominantly in tropical regions. Despite its widespread occurrence, it is frequently underdiagnosed and neglected, posing significant health risks, particularly to immunocompromised individuals. This parasite's life cycle includes a concerning capability for autoinfection, potentially leading to hyperinfection syndrome with high mortality rates. Alcoholism is recognized as a major risk factor for exacerbating S. stercoralis infections due to its harmful impact on the immune system. Chronic alcohol consumption impairs adaptive immunity by reducing T-cell and B-cell function, which facilitates parasitic infections. This review examines the complex relationship between alcohol abuse and strongyloidiasis, emphasizing the molecular mechanisms involved. Diagnostic challenges and treatment options, particularly the efficacy of antiparasitic drugs like ivermectin, are also discussed. Understanding these interactions is essential for developing improved diagnostic and therapeutic strategies to combat strongyloidiasis, especially among vulnerable populations, highlighting areas for future study.
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来源期刊
Toxicology Reports
Toxicology Reports Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
7.60
自引率
0.00%
发文量
228
审稿时长
11 weeks
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