用于乳腺癌近红外触发光动力疗法的藻酸盐功能化和 4T1 细胞膜包被多任务纳米颗粒系统:体外细胞和体内小鼠模型

IF 6.5 2区 材料科学 Q1 MATERIALS SCIENCE, COMPOSITES
Zhiyuan Fan , Yumeng Zhang , Yuheng Shao , Xiao Jiang , Yunfei Ye , Jinglan Zhou , Meihong Wu , Liang Yang
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引用次数: 0

摘要

最近,化学动力疗法(CDT)和光动力疗法(PDT)的联合治疗是众所周知的乳腺肿瘤治疗策略。重要的是,量身定制的纳米药物要具有独特的个性化特性,包括纳米载体的适用性和有效靶向能力,这就要求对肿瘤微环境有详尽的了解。最近,研究人员设计了一种智能上转换纳米粒子(UCNPs),它具有独特的特性,可实现对肿瘤微环境的靶向反应。在本研究中,我们首次将氧化海藻酸钠包膜和4T1癌细胞膜包膜的上转换纳米粒子(4TUCNP@SMZ)结合起来,用于乳腺癌靶向治疗。这种纳米粒子可通过静电作用形成,具有良好的生物相容性,可增加正常细胞和癌细胞对其的吸收。制成的海藻酸盐和 4T1 膜功能化上转换纳米粒子对局部乳腺癌的靶向给药系统大有裨益,并能通过化学动力疗法(CDT)和光动力疗法(PDT)显著抑制肿瘤的发展。肿瘤细胞更容易受到氧化应激的影响,也可能是由于 4TUCNP@SMZ 纳米颗粒消耗了细胞内的 GSH。体外细胞模型(4T1 和 MCF-7)、体内肿瘤模型和组织学观察表明,4TUCNP@SMZ 纳米粒子能有效靶向乳腺肿瘤微环境,抑制乳腺癌细胞。该报告表明,多功能海藻酸盐功能化纳米粒子是一种治疗乳腺癌的多功能光疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alginate-functionalized and 4T1 cell membrane-coated multi-tasking nanoparticulate system for near-infrared-triggered photodynamic therapy on breast cancer: In vitro cellular and in vivo mice models
Recently, combination treatment of chemo-dynamic therapy (CDT) and photodynamic therapies (PDT) is well-known and prominent therapeutic strategy for breast tumor. Importantly, tailored nanomedicines with unique personalized properties including nanocarrier suitability and effective targeting ability that requires the exhaustive understanding of tumor microenvironment. Recently, researchers have designed a smart upconversion nanoparticles (UCNPs) that have unique characteristics to achieve targeting for respond tumor microenvironment. In the present study, we first time fabricated a novel combination of oxidized sodium alginate-enveloped and 4T1 cancer cell membrane-coated up-conversion nanoparticles (4TUCNP@SMZ) were engineered for breast cancer-targeted therapy. The nanoparticles could be formed via electrostatic interaction, which showed excellent biocompatibility, increased cellular uptake with normal and cancer cells. The fabricated Alginate and 4T1-membrane functionalized up-conversion nanoparticles significantly benefitted to targeted delivery system for local breast cancer and prominently inhibit tumor development via chemo-dynamic therapy (CDT) and PDT. The greater susceptibility of tumor cells to oxidative stress may also result from the depletion of intracellular GSH by the 4TUCNP@SMZ nanoparticles. The in vitro cell models (4T1 and MCF-7), in vivo tumor model and histological observation demonstrated that 4TUCNP@SMZ nanoparticles effectively targeted to breast tumor microenvironment and inhibit breast cancer cells. This report suggested that multifunctional Alginate-functionalized nanoparticles are a versatile agent for phototherapy for breast cancer treatment.
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来源期刊
Composites Communications
Composites Communications Materials Science-Ceramics and Composites
CiteScore
12.10
自引率
10.00%
发文量
340
审稿时长
36 days
期刊介绍: Composites Communications (Compos. Commun.) is a peer-reviewed journal publishing short communications and letters on the latest advances in composites science and technology. With a rapid review and publication process, its goal is to disseminate new knowledge promptly within the composites community. The journal welcomes manuscripts presenting creative concepts and new findings in design, state-of-the-art approaches in processing, synthesis, characterization, and mechanics modeling. In addition to traditional fiber-/particulate-reinforced engineering composites, it encourages submissions on composites with exceptional physical, mechanical, and fracture properties, as well as those with unique functions and significant application potential. This includes biomimetic and bio-inspired composites for biomedical applications, functional nano-composites for thermal management and energy applications, and composites designed for extreme service environments.
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