通过水凝胶包裹 G-Rh2 原位疫苗和全身免疫疗法重塑肿瘤免疫微环境

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-09-27 DOI:10.1016/j.mtbio.2024.101281

Chunhua Li , Dan Lei , Yudong Huang , Yuanhao Jing , Wanru Wang , Lanqi Cen , Zijian Wei , Anni Chen , Xiaoyu Feng , Yushu Wang , Lixia Yu , Ying Chen , Rutian Li

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引用次数: 0

摘要

人参皂苷 Rh2（G-Rh2）是中药中一种重要的生物活性化合物，因其强大的药理特性，特别是其强大的抗肿瘤作用而闻名于世。然而，由于其水溶性差、生物利用度有限，因此有必要开发一种新型的给药方法。在本研究中，我们利用吲哚菁绿羧酸-羟丙基纤维素-松香酸-牛血清白蛋白水凝胶（ICG-HPC-AA/BSA 水凝胶）作为肿瘤原位疫苗，以增强 G-Rh2 的渗透性、保留性和肿瘤靶向疗效。我们在 H22 肝癌和 CT26 结肠癌小鼠模型中研究了 G-Rh2 水凝胶与全身性 PD-1 抗体联合治疗的疗效。此外，我们还探索了受这种原位疫苗策略影响的肿瘤免疫微环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy

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Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy

Ginsenoside Rh2 (G-Rh2) is a vital bioactive compound in Traditional Chinese Medicine, celebrated for its strong pharmacological properties, particularly its potent antitumor effects. However, its poor water solubility and limited bioavailability have necessitated the development of a novel drug delivery method. In this study, we utilized an indocyanine green carboxylic acid-hydroxypropyl cellulose-abietic acid-bovine serum albumin hydrogel (ICG-HPC-AA/BSA hydrogel) as a tumor in situ vaccine to enhance the permeability, retention, and tumor-targeted therapeutic efficacy of G-Rh2. We examined the therapeutic impact of a G-Rh2-loaded hydrogel combined with systemic PD-1 antibody treatment in murine models of H22 liver cancer and CT26 colon cancer. Additionally, we explored the immune microenvironment of the tumors influenced by this in situ vaccination strategy.

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).