COVID 19 中的高纤维蛋白溶解状态及其与血脂参数的相关性

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-10-08 DOI:10.1016/j.cegh.2024.101811

Abhilash Sharma , Anupama Hegde , Nandini M. , Sowndarya K. , Rukmini M.S. , Ashok Prabhu K.

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引用次数: 0

摘要

背景科罗纳病毒病 2019（COVID 19）与全身影响有关，尤其涉及呼吸系统和心血管系统。这种疾病的独特之处在于弥散性血管内凝血，凝血系统异常导致纤维蛋白降解产物过多，可独立预测死亡率。我们将通常可预测心血管疾病（CVD）的血脂参数异常与作为 COVID-19 患者风险标志物的 D-二聚体水平进行了比较。方法我们对 30-70 岁确诊为 COVID-19 的患者进行了为期 5 个月的医院横断面研究。根据 D-二聚体水平将患者分为以下几组：第一组为 0.5 μg/ml（正常），第二组为 0.5-2.0 μg/ml（中高），第三组为 2.0 μg/ml（极高）。结果所选 COVID-19 患者的平均年龄为 49.3 ± 19.1 岁，其中男性 63 人，女性 37 人（2:1）。D-二聚体水平明显偏高，与总胆固醇、血浆致动脉粥样硬化指数（AIP）呈弱正相关。第二组的总胆固醇、低密度脂蛋白和非高密度脂蛋白明显升高。各组的 AIP 均呈上升趋势。结论虽然在 COVID-19 患者中观察到 D-二聚体、TG 和 AIP 整体上升，但根据 D-二聚体状态进行分类，发现 LDL 下降，AIP 上升，这与疾病状态恶化有关。

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Hyper fibrinolysis state in COVID 19 and its correlation to lipid parameters

Background

Coronavirus disease 2019 (COVID 19) is associated with systemic effects involving especially the respiratory and cardiovascular system. The unique features of this condition are disseminated intravascular coagulation, excess fibrin degradation products due to abnormality in the coagulation system that could independently predict mortality. Abberations in lipid parameters that normally predict cardiovascular disease (CVD) were compared with D-dimer levels as risk markers in patients with COVID 19.

Methods

A hospital based cross sectional study was conducted over a period of five months in patients aged 30–70 years diagnosed with COVID-19. The patients were categorised based on the D-dimer levels as: Group I < 0.5 μg/ml (Normal), Group II 0.5–2.0 μg/ml (Intermediate high), Group III >2.0 μg/ml (Very high). The lipid parameters, atherogenic indices were compared between the three groups.

Results

The mean age of the selected COVID-19 patients was 49.3 ± 19.1 years of which 63 were males and 37 females (2:1). Significantly high D-dimer levels were detected which had a weak positive correlation with TG, Atherogenic Index Plasma (AIP). Significant rise in TC, LDL and Non-HDL was seen in Group II. Increasing trend of AIP was seen across the groups. D-dimer showed a weak positive correlation with TG, AIP and statistically non-significant negative correlation with rest of the lipid parameters.

Conclusion

Though an overall increase in D-dimer, TG and AIP was observed in COVID-19 patients, categorization based on D-dimer status detected lowering LDL and increasing AIP on deterioration of disease state.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.