关于希夫碱铁 (III) 复合物在乳腺癌细胞中的作用的新见解，用于临床放射治疗

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2024-10-09 DOI:10.1016/j.apradiso.2024.111546

Noor Nabilah Talik Sisin , Raizulnasuha Ab Rashid , Reduan Abdullah , Arifah Nazirah Abdullah , Norhayati Dollah , Merfat Algethami , Awatef S. Assran , Faizal Mohamed , Wan Nordiana Rahman

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引用次数: 0

摘要

目的乳腺癌是全球关注的重大健康问题，研究人员努力提高放射治疗的效果，同时尽量减少副作用。希夫碱铁（III）配合物是癌症放疗中可用作放射增敏剂或放射保护剂的前瞻性元素之一。本研究探讨了希夫碱（配体 2；L2）与铁（III）在临床放疗中对 MCF-7 乳腺癌细胞的潜在影响。用不同剂量的 6 MV 兆伏特光子、6 MeV 电子和高剂量率近距离放射疗法（HDR）192Ir 源对细胞进行照射。结果观察到，Fe(III)-L2 复合物被细胞核内化，对细胞没有任何影响。有趣的是，Fe(III)-L2 复合物具有放射保护作用，这为将金属离子复合物作为放射保护剂应用于癌症放疗提供了令人感兴趣的见解。Fe(III)-L2 复合物还具有清除自由基的活性，这进一步证明了其抗氧化特性和放射保护作用。研究结果表明，Fe(III)-L2 复合物有可能作为放射保护剂应用于临床放射治疗。

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A new insight on the effects of Schiff Base Iron (III) complexes in breast cancer cells for clinical radiotherapy

Purpose

Breast cancer is a significant global health concern, and researchers strive to enhance radiotherapy outcomes while minimizing the side effects. Schiff Base Iron (III) Complexes are one of the prospective elements that can be used as radiosensitizer or radioprotective agents in cancer radiotherapy. This study investigates the potential effects of Schiff base (ligand 2; L²) with Fe(III) in MCF-7 breast cancer cells under clinical radiotherapy treatment.

Methods

The effects of the Schiff Base Iron (III) Complexes were measured using clonogenic assay with MCF-7 breast cancer cells. The cells were irradiated with megavoltage 6 MV photon, 6 MeV electron and high dose rate (HDR) brachytherapy with ¹⁹²Ir source at different doses. Intercellular localization of Fe(III)-L² complexes and antioxidant activities were also investigated.

Results

The Fe(III)-L² complexes were observed to be internalized by cellular nuclei without any effects on the cells. Interestingly, the Fe(III)-L2 complexes indicate radioprotective effects which provide intriguing insight towards application of metal ions complexes as radioprotector in cancer radiotherapy. The Fe(III)-L2 complexes also exhibit scavenging activities of free radical which further proved the antioxidative properties and radioprotective effects.

Conclusion

The Fe(III)-L² complexes show the radioprotective effects and antioxidant properties in MCF-7 cells, particularly for HDR brachytherapy. The findings suggest potential applications of the Fe(III)-L² complexes as radioprotector agents in clinical radiotherapy.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.