人类疾病中的液-液相分离：功能、机制和治疗

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today Pub Date : 2024-10-07 DOI:10.1016/j.nantod.2024.102521

Tongqing Yue , Fei Zhang , Yanan Wei, Zejun Wang

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引用次数: 0

摘要

细胞被非膜细胞器和膜封闭细胞器分隔成功能区，确保各种细胞活动在空间和时间上以受控方式进行。越来越多的证据表明，细胞内通过液-液相分离（LLPS）形成了大量非膜区室，统称为生物分子凝聚体或液滴。相分离的凝聚体在许多生物活动和细胞内时空调节中发挥作用，如细胞转录、染色质维持、信号转导和免疫反应。然而，异常的相分离和转化与许多重大人类疾病密切相关。这篇综述全面总结了生物大分子凝聚物形成的详细机制和生理功能，并探讨了阐明由异常 LLPS 引起的各种人类疾病的病理机制及其治疗方案的最新进展。

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Liquid-liquid phase separation in human diseases: Functions, mechanisms and treatments

Cells are separated into functional regions by non-membrane organelles and membrane-enclosed organelles, ensuring that various cellular activities occur in a controlled manner in space and time. There is increasing evidence that large numbers of non-membrane compartments, collectively referred to as biomacromolecular condensates or droplets, are formed in cells through liquid-liquid phase separation (LLPS). Phase-separated condensates play a role in numerous biological activities and intracellular spatiotemporal regulation, such as cellular transcription, chromatin maintenance, signal transduction, and immune response. However, abnormal phase separation and transformation are closely linked to many major human diseases. This review comprehensively summarizes the detailed mechanisms of biomacromolecular condensates formation and physiological functions, and discusses the latest progress in elucidating the pathological mechanisms of various human diseases caused by abnormal LLPS and their treatment options.

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.