酒精使用障碍和童年创伤患者杏仁核-额叶通路的功能连接性增强

Q4 Neuroscience
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引用次数: 0

摘要

童年创伤(CT)经常与酒精使用障碍(AUD)并发,并且与治疗效果不佳有关。我们已经证明,有童年创伤史的酒精使用障碍患者的杏仁核结构连接性降低。在此,我们还旨在研究患有 CT(AUD-CT)和未患有 CT(AUD-noCT)的 AUD 患者的前边缘功能连接(FC)。根据 CT 的研究结果,我们推测 AUD-CT 患者杏仁核与前额叶皮层的功能连通性降低,治疗效果也会比 AUD-noCT 患者更差。我们对戒断的 AUD 住院患者和健康对照组(HCs)进行了静息状态 fMRI 扫描。我们使用种子连接(SBC)和兴趣区对兴趣区(ROI-ROI)分析比较了AUD-CT(21人)、AUD-noCT(22人)和HC(27人)之间的双侧杏仁核FC。在入院治疗和三个月随访时对社会人口学变量和酒精特异性变量(戒酒天数百分比,PDA)进行了评估。儿童创伤问卷(CTQ)评估创伤的严重程度。SBC分析显示,与HC相比,AUD-CT显示左侧和右侧杏仁核与内侧前额叶皮层和左侧扣带回的FC增加。AUD-CT 显示左侧杏仁核与右侧杏仁核以及右侧杏仁核与内侧前额叶皮层的 ROI-ROI FC 增加。AUD-CT 中杏仁核、内侧前额叶皮层和扣带回的 FC 增加可能是对杏仁核结构连接性降低的一种补偿性适应。AUD-CT中FC的这些特定改变可能代表了AUD的一种可区分的神经生物学亚型,可能是其复杂的临床表现和较差的治疗效果的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma
Childhood trauma (CT) often co-occurs with alcohol use disorder (AUD) and is associated with poor treatment outcome. We could demonstrated that patients with AUD and a history of childhood trauma showed reduced structural connectivity of the amygdala. Here, we additionally aimed to investigate fronto-limbic functional connectivity (FC) in patients with AUD with (AUD-CT) and without (AUD-noCT) CT. Based on findings in CT, we hypothesized reduced FC of the amygdala with the prefrontal cortex in AUD-CT and worse treatment outcome compared to AUD-noCT.
Resting state fMRI scans were acquired in abstinent inpatients with AUD and healthy controls (HCs). We compared bilateral amygdala FC between AUD-CT (n = 21), AUD-noCT (n = 22), and HC (n = 27) using seed-based connectivity (SBC) and region-of-interest to region-of-interest (ROI-ROI) analysis. Sociodemographic and alcohol-specific variables (percent days abstinent, PDA) were assessed at treatment admission and three-month follow-up. The Childhood Trauma Questionnaire (CTQ) assessed trauma severity. SBC analysis revealed that AUD-CT showed increased FC of the left and right amygdala with the medial prefrontal cortex and left paracingulate gyrus compared to HC. AUD-CT showed increased ROI-ROI FC of the left with the right amygdala and the right amygdala with the medial prefrontal cortex. Moreover, AUD-CT exhibited a greater reduction of PDA at three-month follow-up compared to AUD-noCT.
Increased FC of the amygdala, the medial prefrontal cortex, and paracingulate gyrus in AUD-CT might be a compensatory adaption to the reduced structural connectivity of the amygdala. Those specific alterations of FC in AUD-CT may represent a distinguishable neurobiological subtype of AUD, possibly underlying the complex clinical picture and worse treatment outcome.
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
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