从菌群失调到疾病:追踪肠道微生物群在新生儿败血症中的作用

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Faiza Iqbal , Padmaja A. Shenoy , N. Siva , K.E. Vandana , Jayashree Purkayastha , Leslie Edward S. Lewis
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引用次数: 0

摘要

导言新生儿败血症仍然是一个严重的健康问题,严重影响了早产儿的发病率和死亡率。肠道微生物菌群失调被认为是影响败血症易感性的关键因素。本研究旨在通过追踪早产新生儿肠道微生物群的发展来阐明这些关联:一项前瞻性队列研究于 2021 年 1 月至 2023 年 9 月在印度卡纳塔克邦的一家三级护理医院进行,涉及 182 名早产新生儿(胎龄 37 周,出生体重 1500 克)。共定义了两个队列:队列 1(健康新生儿)和队列 2(患有败血症的新生儿)。第 4 天和第 14 天采集粪便样本进行微生物分析。研究包括 182 名新生儿,平均分为两组。第 4 天,第 1 组中大肠杆菌和肺炎克雷伯菌的比例分别为 45% 和 44%,到第 14 天分别降至 40.7% 和 40.7%。相反,双歧杆菌却从 30.8% 增加到 52.7%。组群 2 的致病菌持续率较高,肺炎克雷伯菌从 70.3% 增加到 74.7%,大肠杆菌从 38.5% 增加到 51.6%。分娩方式对肠道菌群的影响很大,NVD 与较高的有益菌(粪肠球菌和双歧杆菌)流行率有关。分娩方式和产前抗生素暴露等因素会对肠道微生物群的组成产生重大影响,从而影响感染的易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From dysbiosis to disease: Tracing gut microbiota's role in neonatal sepsis

Introduction

Neonatal sepsis remains a critical health issue, contributing significantly to morbidity and mortality among preterm infants. Dysbiosis, an imbalance in gut microbiota, is increasingly recognized as a key factor influencing the susceptibility to sepsis. This study aims to elucidate these associations by tracing gut microbiota development in preterm neonates.

Method

ology: A prospective cohort study was conducted at a tertiary care hospital in Karnataka, India, involving 182 preterm neonates (gestational age <37 weeks, birth weight <1500 g) from January 2021 to September 2023. Two cohorts were defined: Cohort 1 (Healthy neonates) and Cohort 2 (Neonates with sepsis). Stool samples were collected on day 4 and day 14 for microbiological analysis. Conventional culture techniques were used to identify bacterial isolates.

Results

The study included 182 neonates, equally divided between two cohorts. On Day 4, Cohort 1 had 45 % E. coli and 44 % Klebsiella pneumoniae, which decreased to 40.7 % and 40.7 % by Day 14, respectively. Conversely, Bifidobacterium spp. increased from 30.8 % to 52.7 %. Cohort 2 exhibited higher persistence of pathogenic bacteria, with Klebsiella pneumoniae increasing from 70.3 % to 74.7 % and E. coli from 38.5 % to 51.6 %. Mode of delivery significantly influenced gut flora, with NVD linked to higher beneficial bacteria prevalence (Enterococcus faecalis and Bifidobacterium spp.).

Conclusion

The study highlights significant differences in gut microbial patterns between healthy and sepsis neonates, emphasizing the role of initial gut colonization in neonatal health outcomes. Factors such as delivery mode and prenatal antibiotic exposure significantly impact gut microbiota composition, influencing infection susceptibility.
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来源期刊
Clinical Epidemiology and Global Health
Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
4.60
自引率
7.70%
发文量
218
审稿时长
66 days
期刊介绍: Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.
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