用于转移性晚期前列腺癌光动力疗法的具有增强抗肿瘤和抗血管双重作用的双靶向小分子光敏剂

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-10-02 DOI:10.1016/j.dyepig.2024.112476

Juanjuan Chen , Jiaqi Xu , Qilu Wang , Feifei Lin , Xueqing Zhang , Lirui Tang , Jinping Xue , Jinluan Li

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引用次数: 0

摘要

晚期前列腺癌被认为是一种致命疾病，其特点是治疗方案有限、预后不佳以及与血管生成密切相关的大量肿瘤转移。光动力疗法因其对肿瘤细胞的局灶性损伤，以及抗血管生成和抗肿瘤免疫能力，成为治疗高转移率和高致死率的晚期前列腺癌的一种前景广阔且安全的治疗方式。本文介绍了一种肿瘤靶向血管破坏剂 ASA-404 与光敏剂 ZnPc 共轭，用于前列腺癌靶向治疗并提高血管破坏效率。值得注意的是，这种新型有机小分子光敏剂 Pc-ASA 具有明确的化学结构和纯度，以及良好的光物理和光化学性质，有利于临床批准和应用。Pc-ASA 可在前列腺癌细胞和血管内皮细胞中积聚。此外，ASA-404 的共轭还能增强 Pc-ASA 对前列腺癌细胞和血管内皮细胞的光动力抗癌效果。最终，PC-ASA 能成功抑制前列腺癌细胞的迁移和转移，在晚期前列腺癌的治疗中具有显著优势。我们的研究可能会为肿瘤和血管双靶向小分子光敏剂的开发打开一扇窗，有望通过抗肿瘤和抗血管双重作用模式实现对转移性晚期前列腺癌的安全高效治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A dual-targeted small-molecule photosensitizer with enhanced dual antitumor and anti-vascular effect for metastatic advanced prostate cancer photodynamic therapy

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A dual-targeted small-molecule photosensitizer with enhanced dual antitumor and anti-vascular effect for metastatic advanced prostate cancer photodynamic therapy

Advanced prostate cancer is regarded as a fatal disease, characterized by limited treatment options, poor prognosis and considerable tumor metastasis closely related to angiogenesis. Photodynamic therapy emerges as a promising and safe therapeutic modality for advanced prostate cancer with high metastasis and high fatality rate due to its focal damage to tumor cells, as well as its anti-angiogenesis and antitumor immunity capabilities. Herein, a tumor-targeting vascular disrupting agent ASA-404 was introduced to conjugate with a photosensitizer ZnPc for targeted prostate cancer treatment and enhanced vascular-disrupting efficiency. Notably, this novel organic small-molecule photosensitizer Pc-ASA possess a well-defined chemical structure and purity, as well as good photophysical and photochemical properties, which are of benefit for clinical approval and application. Pc-ASA prefers to accumulate in both prostate cancer cells and vascular endothelial cells. Moreover, the conjugation of ASA-404 boosts the photodynamic anticancer effect of Pc-ASA towards both prostate cancer cells and vascular endothelial cells. Ultimately, PC-ASA can successfully inhibit the migration and metastasis of prostate cancer cells, offering significant advantages in advanced prostate cancer management. Our study might open a window in the development of the tumor and vascular dual-targeted small-molecule photosensitizers, with the potential to achieve safe and efficient treatment of metastatic advanced prostate cancer through dual mode of antitumor and anti-vascular action.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.