光对白细胞介素-10 的影响:初步研究

IF 3.7 Q2 IMMUNOLOGY
Liza Mekschrat , Michael Göring , Bjarne Schmalbach , Nicolas Rohleder , Katja Petrowski
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引用次数: 0

摘要

光线会影响昼夜节律,包括压力荷尔蒙皮质醇的昼夜节律。据观察,皮质醇反过来会促进抗炎细胞因子 IL-10 的表达。因此,细胞因子 IL-10 是否也会受到光线的影响,或许与皮质醇的昼夜变化一致,这一点令人感兴趣。因此,这项高度标准化的初步睡眠实验室研究以健康成年男性为对象,调查了不同光照对血液中 IL-10 和皮质醇浓度的潜在影响。在受试者间设计中,N = 42 名参与者在起床后分别暴露于明亮、昏暗、蓝色或红色的光线中。以光线条件和时间(跨越八个 IL-10 和皮质醇采样点)为因素进行了两个混合模型分析。此外,还计算了皮质醇和 IL-10 的曲线下面积测量值(AUCg 和 AUCi)。在所有条件下,IL-10 和皮质醇浓度都随时间发生了显著变化。然而,没有一种光照条件对 IL-10 或皮质醇水平的影响比其他条件更大。就皮质醇而言,蓝光条件下的总输出量(AUCg)尤其大。要深入了解光照类型或皮质醇水平是否对天然 IL-10 浓度有影响,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The influence of light on Interleukin-10: A preliminary study
Light influences circadian rhythms, including that of the stress hormone cortisol. Cortisol, in turn, has been observed to promote expression of the anti-inflammatory cytokine IL-10. It is thus of interest whether the cytokine IL-10 is also influenced by light, perhaps in accord with the diurnal variations in cortisol. Hence, this highly standardized preliminary sleep laboratory study in healthy adult men investigated a potential influence of different light exposure on IL-10 and cortisol concentrations in blood. In a between-subject design, N = 42 participants were exposed to either bright, dim, blue or red light after wake-up. Two mixed-model analyses with the factors of light condition and time (across eight IL-10 and cortisol sampling points) were conducted. Additionally, area under the curve measurements (AUCg and AUCi) were calculated for both cortisol and IL-10. Across all conditions, IL-10 and cortisol concentrations significantly changed over time. However, none of the light conditions exerted a greater influence on IL-10 or cortisol levels than others. For cortisol, there was greater total output (AUCg) in the blue-light condition in particular. Further research is needed to gain insight into whether or not types of light or cortisol levels have a hand in influencing natural IL-10 concentrations.
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
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审稿时长
97 days
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