Rumex abyssinicus Jacq.的根茎：揭示五种新的蒽醌类化合物（Rumabynosides A-E）并综述其植物化学物质的保肝潜力

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-10-07 DOI:10.1016/j.phytol.2024.09.004

Leopoldine T. Lonkeng , Paul Eckhardt , Borice.T. Tsafack , Robert Forster , Beaudelaire K. Ponou , Rémy B. Teponno , Télesphore B. Nguelefack , Till Opatz , Léon A. Tapondjou

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引用次数: 0

摘要

从阿比西尼亚鲁梅克斯（Rumex abyssinicus）根茎中分离出了五种迄今未报道过的蒽醌苷衍生物--鲁马宾苷 A-E（1-5），以及二十种以前报道过的化合物。其中三种新的蒽醌类化合物的糖基上带有一个不常见的取代基（3-羟基-3-甲基戊二酰基）。通过紫外、红外、HRESIMS、1D NMR（1H 和 13C NMR）和 2D NMR（HSQC、COSY、HMBC、NOESY）等综合分析，阐明了它们的结构。文献调查显示，其中一些分离出的化合物具有保肝活性，因此这种植物在传统医学中被广泛用于治疗各种肝病。

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Rhizomes of Rumex abyssinicus Jacq.: Unveiling five new anthraquinones (Rumabynosides A-E) and a review on hepatoprotective potential of its phytochemicals

Five hitherto unreported anthraquinone glycoside derivatives, rumabynosides A–E (1–5), along with twenty previously reported compounds, were isolated from the rhizomes of Rumex abyssinicus. Three of these new anthraquinones carried an uncommon substituent (3-hydroxy-3-methylglutaroyl) attached to the sugar moiety. Their structures were elucidated by comprehensive UV, IR, HRESIMS, 1D NMR (¹H and ¹³C NMR) and 2D NMR (HSQC, COSY, HMBC, NOESY) analyses. A literature survey revealed hepatoprotective activities of some of the isolated compounds, thus adding weight to the wide use of this plant against various liver diseases in traditional medicine.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.