蒿叶中的倍半萜及其体外抗炎活性评估

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-10-04 DOI:10.1016/j.phytol.2024.09.008

Wu Yi-xun , Wang Xiao-wei , Wang Hai-bo , Qin Zi-Fei , Jia An , Wei Wen-jun , Guo Tao

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引用次数: 0

摘要

研究人员从菊科植物青蒿（Artemisia argyi Lévl. et Vant）叶片的氯仿部分获得了两种未报道的倍半萜类化合物，即 7-en-13-hytanaphallin (1) 和 8´-en-achillinin C (2)，以及两种已知的倍半萜二聚体。通过 HR-ESI-MS、IR、1D 和 2D NMR 以及电子圆二色性分析，确定了两种新化合物的平面结构和绝对构型。两种已知的倍半萜类化合物，即 argyinolide O (3) 和 (+)-8-acetylarteminolide (4)，对 LPS 诱导的 RAW264.7 细胞产生的 NO 具有强效活性，IC50 值分别为 3.6 和 9.8 μM。

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Sesquiterpenes from the leaves of Artemisia argyi and evaluation of their in vitro anti-inflammatory activities

Two unreported sesquiterpenoids, 7-en-13-hytanaphallin (1) and 8´-en-achillinin C (2) along with two known sesquiterpenoid dimers were obtained from chloroform parts in the leaves of Artemisia argyi Lévl. et Vant, belonging to Asteraceae family. The planar structures and absolute configurations of two new compounds were characterized by HR-ESI-MS, IR, 1D and 2D NMR, and electronic circular dichroism analyses. Two known sesquiterpenoids, argyinolide O (3) and (+)-8-acetylarteminolide (4), exhibited potent activities against NO production from LPS-induced RAW264.7 cells with IC₅₀ values of 3.6 and 9.8 μM, respectively.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.