Mohammed Dawood Salman , Yasmin Md Radzi , Azhar Abdul Rahman , Ammar A. Oglat
{"title":"用于放射治疗的基于聚甲基丙烯酸甲酯凝胶 (PMMAG) 的新型 3D 聚合物凝胶剂量计:超声波评估","authors":"Mohammed Dawood Salman , Yasmin Md Radzi , Azhar Abdul Rahman , Ammar A. Oglat","doi":"10.1016/j.radphyschem.2024.112286","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112286"},"PeriodicalIF":2.8000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel 3D polymer gel dosimeter based on polymethyl methacrylate gel (PMMAG) for radiotherapy: Ultrasonic evaluation\",\"authors\":\"Mohammed Dawood Salman , Yasmin Md Radzi , Azhar Abdul Rahman , Ammar A. Oglat\",\"doi\":\"10.1016/j.radphyschem.2024.112286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.</div></div>\",\"PeriodicalId\":20861,\"journal\":{\"name\":\"Radiation Physics and Chemistry\",\"volume\":\"226 \",\"pages\":\"Article 112286\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation Physics and Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0969806X24007783\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Physics and Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969806X24007783","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
A novel 3D polymer gel dosimeter based on polymethyl methacrylate gel (PMMAG) for radiotherapy: Ultrasonic evaluation
This study investigates the characteristics of a novel polymer gel dosimeter (PMMAG) for radiotherapy applications, focusing on its radiation absorption and sensitivity properties. The PMMAG dosimeters were evaluated using both UV–vis spectrophotometry and ultrasonic techniques. The results of the study, UV–vis analysis revealed a significant increase in dose response with the introduction of a cross-linker, peaking at a monomer-to-cross-linker ratio of 5:3. Sensitivity analysis indicated optimal sensitivity at this ratio, with values reaching 0.021 a.u./Gy. Ultrasound evaluation showed that the speed of sound and attenuation coefficient demonstrated a linear relationship and a strong positive correlation with an increase in the applied radiation dose, with the highest sensitivity observed at 8 Gy. The optimal sample exhibited the highest dose-response values at both 4 Gy and 8 Gy doses. Sensitivity values ranged from 2.1 to 2.75. The ultrasonic measurements demonstrated a significantly larger dynamic range in dose response curves compared to UV–vis dose-response data. It is concluded that ultrasound shows great potential as a technique for the evaluation of polymer gel dosimeters. The PMMAG can be introduced as a novel dosimeter for ionizing radiation dosimetry, validated through both optical and ultrasound assessment methods. The consistent and reliable performance of the PMMAG dosimeters makes them suitable for various applications in radiation therapy.
期刊介绍:
Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.