构建光热响应型 PEEK 复合植入体的功能和结构,促进骨再生和骨植入体整合

IF 8.3 1区 材料科学 Q1 MATERIALS SCIENCE, COMPOSITES
Wenchao Li , Zhengnan Su , Yanru Hu , Lihui Meng , Fang Zhu , Bin Xie , Zilin Zhou , Shuojie Cui , Meng Wang , Qingzhi Wu , Shun Yao
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引用次数: 0

摘要

尽管聚醚醚酮(PEEK)已被广泛应用于骨科手术,但其临床疗效却因骨再生效果不佳和骨结合力不足而受到质疑。本文受中国传统建筑艺术中榫卯结构的启发,通过在 PEEK 中加入氧化石墨烯(GO)和多巴胺包覆纳米氧化锆(PDA@ZrO2)(即 PGPZ 复合材料),开发出一种新的策略来构建具有锥形锁槽边缘的光热响应 PEEK 复合材料植入体,并以此作为概念验证。PGPZ 复合材料具有更好的机械性能、良好的细胞相容性和血液相容性、优异的抗菌能力以及可通过近红外辐射(NIR)远程控制的成骨活性。兔子颅骨缺损实验表明,对 PGPZ 复合材料植入物进行反复近红外处理可显著加速内源性骨再生。更重要的是,大量新形成的骨在锁沟中形成,与种植体形成互锁的榫卯连接。这项研究不仅为提高 PEEK 复合材料植入物的生物活性以促进骨再生和骨整合的进一步临床应用铺平了道路,还为各种组织工程植入物的结构和功能设计提供了一种新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Functional and structural construction of photothermal-responsive PEEK composite implants to promote bone regeneration and bone-implant integration

Functional and structural construction of photothermal-responsive PEEK composite implants to promote bone regeneration and bone-implant integration
Although poly (ether-ether-ketone) (PEEK) has been widely used in orthopedic surgeries, its clinical efficacy is challenged by ineffective bone regeneration and insufficient osteointegration. Herein, inspired by the Mortise-and-tenon joint in traditional Chinese architectural art, a novel strategy has been developed to construct photothermal-responsive PEEK composite implants, with tapered lock-groove edges as proof of concept, by incorporating graphene oxide (GO) loaded with polydopamine-coated nano-zirconia (PDA@ZrO2) into PEEK (namely PGPZ composite). The PGPZ composite exhibits improved mechanical properties, good cytocompatibility and blood compatibility, excellent antibacterial ability and osteogenic activity remotely controlled by near-infrared irradiation (NIR). The cranial defects experiment on rabbits reveals that repeated NIR treatment on PGPZ composite implant significantly accelerates endogenous bone regeneration. More importantly, abundant newly-formed bone has materialized in the lock grooves, forming interlocked Mortise-and-tenon joints with the implant. This study not only pave the way for further clinical applications of the PEEK composite implants with improved bioactivities to promote bone regeneration and osteointegration, but also providing a novel strategy for structural and functional design of various tissue engineering implants.
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来源期刊
Composites Science and Technology
Composites Science and Technology 工程技术-材料科学:复合
CiteScore
16.20
自引率
9.90%
发文量
611
审稿时长
33 days
期刊介绍: Composites Science and Technology publishes refereed original articles on the fundamental and applied science of engineering composites. The focus of this journal is on polymeric matrix composites with reinforcements/fillers ranging from nano- to macro-scale. CSTE encourages manuscripts reporting unique, innovative contributions to the physics, chemistry, materials science and applied mechanics aspects of advanced composites. Besides traditional fiber reinforced composites, novel composites with significant potential for engineering applications are encouraged.
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