在六氯乙烷存在下使用硫醇对尿嘧啶和原位生成的烯丙酮进行无金属 CH 硫代芳香化反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-10-12 DOI:10.1016/j.tetlet.2024.155320

引用次数: 0

摘要

本文介绍了在 C2Cl6 存在下，用硫醇对尿嘧啶和原位生成的烯丙酮进行硫代芳基化的无金属单锅程序。与其他传统的硫代芳基化技术相比，该方法毒性较低，因为它使用六氯乙烷作为固体氧化剂，这种氧化剂稳定、廉价、易于获得且更容易操作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metal-free CH thioarylation of uracils and in situ generated enaminones using thiols in the presence of hexachloroethane

A metal-free and one-pot procedure for thioarylation of uracils and in situ generated enaminones with thiols in the presence of C₂Cl₆ is introduced. This protocol is a less toxic alternative to other conventional thioarylation techniques because it uses hexachloroethane as a solid oxidant, which is stable, inexpensive, readily available and easier to work with.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.