甘蔗渣木聚糖的化学修饰及其对小鼠肠道微生物群的调节作用

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2024-03-23 DOI:10.1080/07328303.2024.2399517

Guozhu Zhang , Yuan Guan , Xin Zhang , Jing Li , Haishan Chen , Li Zhou , Jun Liang , Xia Li

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引用次数: 0

摘要

难以消化的膳食聚糖的吸收和代谢在维持肠道屏障的完整性和塑造肠道微生物群方面起着至关重要的作用。研究人员利用甘蔗渣中的木聚糖合成了三种木聚糖化学修饰产物，包括羧甲基木聚糖、木聚糖-锌复合物和羧甲基木聚糖-锌复合物。随后研究并比较了改性前后的木聚糖对小鼠肠道屏障和肠道微生物群的潜在影响，结果发现小鼠肠道微生物群发生了明显变化。结果表明，化学改性木聚糖产品有可能诱导肠道微生物群发挥特定的调节功能。

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Chemical modifications of xylan from sugarcane bagasse and their regulatory effects on gut microbiota in mice

The absorption and metabolism of indigestible dietary glycans play a crucial role in maintaining the integrity of the intestinal barrier and shaping the gut microbiota. Three chemically modified products of xylan, including carboxymethylated xylan, xylan–zinc complex, and carboxymethylated xylan–zinc complex, were synthesized using xylan from sugarcane bagasse. The potential effects of xylan before and after modification on the intestinal barriers and intestinal microbiota of mice were subsequently investigated and compared, revealing distinct changes in the gut microbiota of mice. The results suggest that the chemically modified xylan products have the potential to induce specific regulatory functions on the gut microbiota.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.